BH115_ARATH
ID BH115_ARATH Reviewed; 226 AA.
AC Q9C682;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Transcription factor bHLH115;
DE AltName: Full=Basic helix-loop-helix protein 115;
DE Short=AtbHLH115;
DE Short=bHLH 115;
DE AltName: Full=Transcription factor EN 134;
DE AltName: Full=bHLH transcription factor bHLH115;
GN Name=BHLH115; Synonyms=EN134; OrderedLocusNames=At1g51070;
GN ORFNames=F23H24.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [8]
RP INTERACTION WITH BTS.
RC STRAIN=cv. Columbia;
RX PubMed=20675571; DOI=10.1105/tpc.110.074096;
RA Long T.A., Tsukagoshi H., Busch W., Lahner B., Salt D.E., Benfey P.N.;
RT "The bHLH transcription factor POPEYE regulates response to iron deficiency
RT in Arabidopsis roots.";
RL Plant Cell 22:2219-2236(2010).
RN [9]
RP INTERACTION WITH BTS AND BHLH47/PYE, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=25452667; DOI=10.1104/pp.114.250837;
RA Selote D., Samira R., Matthiadis A., Gillikin J.W., Long T.A.;
RT "Iron-binding E3 ligase mediates iron response in plants by targeting basic
RT helix-loop-helix transcription factors.";
RL Plant Physiol. 167:273-286(2015).
CC -!- SUBUNIT: Homodimer (Probable). Interacts with BTS and BHLH47/PYE
CC (PubMed:20675571, PubMed:25452667). {ECO:0000269|PubMed:20675571,
CC ECO:0000269|PubMed:25452667, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981,
CC ECO:0000269|PubMed:25452667}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9C682-1; Sequence=Displayed;
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DR EMBL; AF488632; AAM10965.1; -; mRNA.
DR EMBL; AC079828; AAG50538.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32618.1; -; Genomic_DNA.
DR EMBL; BT002433; AAO00793.1; -; mRNA.
DR EMBL; BT006273; AAP13381.1; -; mRNA.
DR EMBL; AY085619; AAM62840.1; -; mRNA.
DR PIR; H96547; H96547.
DR RefSeq; NP_175518.1; NM_103985.4. [Q9C682-1]
DR AlphaFoldDB; Q9C682; -.
DR SMR; Q9C682; -.
DR BioGRID; 26754; 3.
DR EnsemblPlants; AT1G51070.1; AT1G51070.1; AT1G51070. [Q9C682-1]
DR GeneID; 841529; -.
DR Gramene; AT1G51070.1; AT1G51070.1; AT1G51070. [Q9C682-1]
DR KEGG; ath:AT1G51070; -.
DR Araport; AT1G51070; -.
DR eggNOG; ENOG502QSHF; Eukaryota.
DR HOGENOM; CLU_078927_0_0_1; -.
DR InParanoid; Q9C682; -.
DR OMA; SRIECCN; -.
DR PhylomeDB; Q9C682; -.
DR PRO; PR:Q9C682; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C682; baseline and differential.
DR Genevisible; Q9C682; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:InterPro.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR044818; ILR3-like.
DR PANTHER; PTHR46133; PTHR46133; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..226
FT /note="Transcription factor bHLH115"
FT /id="PRO_0000358801"
FT DOMAIN 66..117
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 226 AA; 25512 MW; 6C0024AD23DE48A9 CRC64;
MVSPENTNWL SDYPLIEGAF SDQNPTFPWQ IDGSATVSVE VDGFLCDADV IKEPSSRKRI
KTESCTGSNS KACREKQRRD RLNDKFTELS SVLEPGRTPK TDKVAIINDA IRMVNQARDE
AQKLKDLNSS LQEKIKELKD EKNELRDEKQ KLKVEKERID QQLKAIKTQP QPQPCFLPNP
QTLSQAQAPG SKLVPFTTYP GFAMWQFMPP AAVDTSQDHV LRPPVA
