SIM15_DANRE
ID SIM15_DANRE Reviewed; 74 AA.
AC A3KNM5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Small integral membrane protein 15;
GN Name=smim15; ORFNames=si:ch211-198n5.13, zgc:162244;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM15 family. {ECO:0000305}.
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DR EMBL; CR759968; CAP19509.1; -; Genomic_DNA.
DR EMBL; BC133916; AAI33917.1; -; mRNA.
DR EMBL; BC153516; AAI53517.1; -; mRNA.
DR RefSeq; NP_001153418.1; NM_001159946.2.
DR AlphaFoldDB; A3KNM5; -.
DR SMR; A3KNM5; -.
DR STRING; 7955.ENSDARP00000116430; -.
DR PaxDb; A3KNM5; -.
DR Ensembl; ENSDART00000144621; ENSDARP00000116430; ENSDARG00000086699.
DR Ensembl; ENSDART00000182478; ENSDARP00000146390; ENSDARG00000114331.
DR GeneID; 556945; -.
DR KEGG; dre:556945; -.
DR CTD; 643155; -.
DR ZFIN; ZDB-GENE-070410-48; smim15.
DR eggNOG; ENOG502SDBQ; Eukaryota.
DR GeneTree; ENSGT00940000165045; -.
DR HOGENOM; CLU_2687094_0_0_1; -.
DR InParanoid; A3KNM5; -.
DR OMA; SWAEYIV; -.
DR OrthoDB; 1613746at2759; -.
DR PhylomeDB; A3KNM5; -.
DR TreeFam; TF328386; -.
DR PRO; PR:A3KNM5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000086699; Expressed in early embryo and 28 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027877; Smim15.
DR PANTHER; PTHR28644; PTHR28644; 1.
DR Pfam; PF15086; UPF0542; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..74
FT /note="Small integral membrane protein 15"
FT /id="PRO_0000326079"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 53..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 42..74
FT /evidence="ECO:0000255"
SQ SEQUENCE 74 AA; 8549 MW; E7961F1C95B0A845 CRC64;
MIDIKAWAEY VVEWAAKDPY GFLTTVILAL TPLFIASALL SWKLAKMIEA KDREQKKKQK
RQENIAKAKR AKKD