SIM15_HUMAN
ID SIM15_HUMAN Reviewed; 74 AA.
AC Q7Z3B0; B9EJC4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Small integral membrane protein 15;
GN Name=SMIM15; Synonyms=C5orf43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM15 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK291180; BAF83869.1; -; mRNA.
DR EMBL; BX538015; CAD97962.1; -; mRNA.
DR EMBL; CH471123; EAW55009.1; -; Genomic_DNA.
DR EMBL; BC146876; AAI46877.1; -; mRNA.
DR EMBL; BC146881; AAI46882.1; -; mRNA.
DR CCDS; CCDS34165.1; -.
DR RefSeq; NP_001041714.1; NM_001048249.3.
DR AlphaFoldDB; Q7Z3B0; -.
DR SMR; Q7Z3B0; -.
DR BioGRID; 568548; 1.
DR IntAct; Q7Z3B0; 1.
DR STRING; 9606.ENSP00000339324; -.
DR iPTMnet; Q7Z3B0; -.
DR PhosphoSitePlus; Q7Z3B0; -.
DR BioMuta; SMIM15; -.
DR DMDM; 74713347; -.
DR EPD; Q7Z3B0; -.
DR jPOST; Q7Z3B0; -.
DR MassIVE; Q7Z3B0; -.
DR MaxQB; Q7Z3B0; -.
DR PaxDb; Q7Z3B0; -.
DR PeptideAtlas; Q7Z3B0; -.
DR PRIDE; Q7Z3B0; -.
DR ProteomicsDB; 69020; -.
DR TopDownProteomics; Q7Z3B0; -.
DR DNASU; 643155; -.
DR Ensembl; ENST00000339020.8; ENSP00000339324.3; ENSG00000188725.8.
DR Ensembl; ENST00000507416.1; ENSP00000421336.1; ENSG00000188725.8.
DR GeneID; 643155; -.
DR KEGG; hsa:643155; -.
DR MANE-Select; ENST00000339020.8; ENSP00000339324.3; NM_001048249.4; NP_001041714.1.
DR UCSC; uc010iwm.2; human.
DR CTD; 643155; -.
DR GeneCards; SMIM15; -.
DR HGNC; HGNC:33861; SMIM15.
DR HPA; ENSG00000188725; Low tissue specificity.
DR neXtProt; NX_Q7Z3B0; -.
DR OpenTargets; ENSG00000188725; -.
DR PharmGKB; PA162380269; -.
DR VEuPathDB; HostDB:ENSG00000188725; -.
DR eggNOG; ENOG502SDBQ; Eukaryota.
DR GeneTree; ENSGT00390000008903; -.
DR HOGENOM; CLU_2687094_0_0_1; -.
DR InParanoid; Q7Z3B0; -.
DR OMA; SWAEYIV; -.
DR OrthoDB; 1613746at2759; -.
DR PhylomeDB; Q7Z3B0; -.
DR TreeFam; TF328386; -.
DR PathwayCommons; Q7Z3B0; -.
DR SignaLink; Q7Z3B0; -.
DR BioGRID-ORCS; 643155; 7 hits in 1036 CRISPR screens.
DR ChiTaRS; SMIM15; human.
DR GenomeRNAi; 643155; -.
DR Pharos; Q7Z3B0; Tdark.
DR PRO; PR:Q7Z3B0; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q7Z3B0; protein.
DR Bgee; ENSG00000188725; Expressed in ileal mucosa and 194 other tissues.
DR Genevisible; Q7Z3B0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027877; Smim15.
DR PANTHER; PTHR28644; PTHR28644; 1.
DR Pfam; PF15086; UPF0542; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..74
FT /note="Small integral membrane protein 15"
FT /id="PRO_0000326075"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 42..74
FT /evidence="ECO:0000255"
FT VARIANT 23
FT /note="L -> F (in dbSNP:rs4546328)"
FT /id="VAR_039986"
SQ SEQUENCE 74 AA; 8625 MW; 5FB1AD0E251AFE7B CRC64;
MFDIKAWAEY VVEWAAKDPY GFLTTVILAL TPLFLASAVL SWKLAKMIEA REKEQKKKQK
RQENIAKAKR LKKD
