SIM15_MOUSE
ID SIM15_MOUSE Reviewed; 74 AA.
AC Q3UTD9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Small integral membrane protein 15;
GN Name=Smim15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM15 family. {ECO:0000305}.
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DR EMBL; AK139507; BAE24041.1; -; mRNA.
DR EMBL; BC004049; AAH04049.1; -; mRNA.
DR CCDS; CCDS36777.1; -.
DR RefSeq; NP_001041715.1; NM_001048250.2.
DR RefSeq; XP_006517843.1; XM_006517780.1.
DR RefSeq; XP_006517844.1; XM_006517781.1.
DR AlphaFoldDB; Q3UTD9; -.
DR SMR; Q3UTD9; -.
DR STRING; 10090.ENSMUSP00000093110; -.
DR PhosphoSitePlus; Q3UTD9; -.
DR EPD; Q3UTD9; -.
DR PaxDb; Q3UTD9; -.
DR PRIDE; Q3UTD9; -.
DR ProteomicsDB; 261233; -.
DR Ensembl; ENSMUST00000095458; ENSMUSP00000093110; ENSMUSG00000071180.
DR Ensembl; ENSMUST00000223808; ENSMUSP00000153155; ENSMUSG00000071180.
DR Ensembl; ENSMUST00000224361; ENSMUSP00000153283; ENSMUSG00000071180.
DR Ensembl; ENSMUST00000224390; ENSMUSP00000152900; ENSMUSG00000071180.
DR Ensembl; ENSMUST00000225972; ENSMUSP00000153282; ENSMUSG00000071180.
DR Ensembl; ENSMUST00000226042; ENSMUSP00000153340; ENSMUSG00000071180.
DR GeneID; 75616; -.
DR KEGG; mmu:75616; -.
DR UCSC; uc007rut.1; mouse.
DR CTD; 643155; -.
DR MGI; MGI:1922866; Smim15.
DR VEuPathDB; HostDB:ENSMUSG00000071180; -.
DR eggNOG; ENOG502SDBQ; Eukaryota.
DR GeneTree; ENSGT00390000008903; -.
DR HOGENOM; CLU_2687094_0_0_1; -.
DR InParanoid; Q3UTD9; -.
DR OMA; SWAEYIV; -.
DR OrthoDB; 1613746at2759; -.
DR PhylomeDB; Q3UTD9; -.
DR TreeFam; TF328386; -.
DR BioGRID-ORCS; 75616; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Smim15; mouse.
DR PRO; PR:Q3UTD9; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3UTD9; protein.
DR Bgee; ENSMUSG00000071180; Expressed in manus and 221 other tissues.
DR Genevisible; Q3UTD9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027877; Smim15.
DR PANTHER; PTHR28644; PTHR28644; 1.
DR Pfam; PF15086; UPF0542; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..74
FT /note="Small integral membrane protein 15"
FT /id="PRO_0000326076"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 42..74
FT /evidence="ECO:0000255"
SQ SEQUENCE 74 AA; 8591 MW; 571B0F068FB8FE7B CRC64;
MLDIKAWAEY VVEWAAKDPY GFLTTVILAL TPLFLASAVL SWKLAKMIEA REKEQKKKQK
RQENIAKAKR LKKD
