ID   SIM18_HUMAN             Reviewed;          95 AA.
AC   P0DKX4;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Small integral membrane protein 18;
GN   Name=SMIM18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=15885500; DOI=10.1016/j.ygeno.2005.02.009;
RA   Dalla E., Mignone F., Verardo R., Marchionni L., Marzinotto S.,
RA   Lazarevic D., Reid J.F., Marzio R., Klaric E., Licastro D., Marcuzzi G.,
RA   Gambetta R., Pierotti M.A., Pesole G., Schneider C.;
RT   "Discovery of 342 putative new genes from the analysis of 5'-end-sequenced
RT   full-length-enriched cDNA human transcripts.";
RL   Genomics 85:739-751(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- CAUTION: Encoded in intron of the gene GTF2E2 (opposite strand).
CC       Confirmed by numerous ESTs. {ECO:0000305}.
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DR   EMBL; DR033682; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC103959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC102945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS56529.1; -.
DR   RefSeq; NP_001193776.1; NM_001206847.1.
DR   RefSeq; XP_016868432.1; XM_017012943.1.
DR   AlphaFoldDB; P0DKX4; -.
DR   iPTMnet; P0DKX4; -.
DR   PhosphoSitePlus; P0DKX4; -.
DR   BioMuta; SMIM18; -.
DR   DMDM; 460425421; -.
DR   MassIVE; P0DKX4; -.
DR   PaxDb; P0DKX4; -.
DR   PRIDE; P0DKX4; -.
DR   Antibodypedia; 74040; 4 antibodies from 4 providers.
DR   DNASU; 100507341; -.
DR   Ensembl; ENST00000517349.2; ENSP00000428858.1; ENSG00000253457.3.
DR   GeneID; 100507341; -.
DR   KEGG; hsa:100507341; -.
DR   MANE-Select; ENST00000517349.2; ENSP00000428858.1; NM_001206847.2; NP_001193776.1.
DR   UCSC; uc022atn.2; human.
DR   CTD; 100507341; -.
DR   GeneCards; SMIM18; -.
DR   HGNC; HGNC:42973; SMIM18.
DR   HPA; ENSG00000253457; Tissue enhanced (brain, pituitary gland, retina).
DR   neXtProt; NX_P0DKX4; -.
DR   OpenTargets; ENSG00000253457; -.
DR   VEuPathDB; HostDB:ENSG00000253457; -.
DR   eggNOG; ENOG502S8D3; Eukaryota.
DR   GeneTree; ENSGT00410000029064; -.
DR   HOGENOM; CLU_178645_0_0_1; -.
DR   InParanoid; P0DKX4; -.
DR   OMA; MMNSFRK; -.
DR   OrthoDB; 1461792at2759; -.
DR   PathwayCommons; P0DKX4; -.
DR   BioGRID-ORCS; 100507341; 9 hits in 1024 CRISPR screens.
DR   Pharos; P0DKX4; Tdark.
DR   PRO; PR:P0DKX4; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; P0DKX4; protein.
DR   Bgee; ENSG00000253457; Expressed in cortical plate and 79 other tissues.
DR   ExpressionAtlas; P0DKX4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031671; DUF4713.
DR   Pfam; PF15831; DUF4713; 1.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..95
FT                   /note="Small integral membrane protein 18"
FT                   /id="PRO_0000421256"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   95 AA;  11088 MW;  02D6026BDEF80CA7 CRC64;
     MASSHWNETT TSVYQYLGFQ VQKIYPFHDN WNTACFVILL LFIFTVVSLV VLAFLYEVLD
     CCCCVKNKTV KDLKSEPNPL RSMMDNIRKR ETEVV