ID   SIM23_HUMAN             Reviewed;         172 AA.
AC   A6NLE4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 3.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Small integral membrane protein 23;
GN   Name=SMIM23; Synonyms=C5orf50;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-124.
RA   Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT   "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT   human.";
RL   Submitted (OCT-2006) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AC011410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DN930602; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; EG327839; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS87347.1; -.
DR   RefSeq; NP_001276899.1; NM_001289970.1.
DR   AlphaFoldDB; A6NLE4; -.
DR   SMR; A6NLE4; -.
DR   STRING; 9606.ENSP00000331214; -.
DR   BioMuta; SMIM23; -.
DR   PaxDb; A6NLE4; -.
DR   PeptideAtlas; A6NLE4; -.
DR   PRIDE; A6NLE4; -.
DR   ProteomicsDB; 1469; -.
DR   Antibodypedia; 64430; 3 antibodies from 3 providers.
DR   DNASU; 644994; -.
DR   Ensembl; ENST00000523047.4; ENSP00000430818.4; ENSG00000185662.10.
DR   Ensembl; ENST00000639838.1; ENSP00000490990.1; ENSG00000185662.10.
DR   GeneID; 644994; -.
DR   KEGG; hsa:644994; -.
DR   MANE-Select; ENST00000523047.4; ENSP00000430818.4; NM_001289970.2; NP_001276899.1.
DR   UCSC; uc063jql.1; human.
DR   CTD; 644994; -.
DR   DisGeNET; 644994; -.
DR   GeneCards; SMIM23; -.
DR   HGNC; HGNC:34440; SMIM23.
DR   HPA; ENSG00000185662; Tissue enriched (testis).
DR   neXtProt; NX_A6NLE4; -.
DR   OpenTargets; ENSG00000185662; -.
DR   VEuPathDB; HostDB:ENSG00000185662; -.
DR   eggNOG; ENOG502TDUM; Eukaryota.
DR   GeneTree; ENSGT00390000017300; -.
DR   InParanoid; A6NLE4; -.
DR   OMA; CEDKKQT; -.
DR   OrthoDB; 1592023at2759; -.
DR   TreeFam; TF338699; -.
DR   PathwayCommons; A6NLE4; -.
DR   SignaLink; A6NLE4; -.
DR   BioGRID-ORCS; 644994; 1 hit in 152 CRISPR screens.
DR   GenomeRNAi; 644994; -.
DR   Pharos; A6NLE4; Tdark.
DR   PRO; PR:A6NLE4; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A6NLE4; protein.
DR   Bgee; ENSG00000185662; Expressed in left testis and 43 other tissues.
DR   ExpressionAtlas; A6NLE4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027880; DUF4635.
DR   PANTHER; PTHR37865; PTHR37865; 1.
DR   Pfam; PF15466; DUF4635; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..172
FT                   /note="Small integral membrane protein 23"
FT                   /id="PRO_0000341237"
FT   TOPO_DOM        1..36
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..53
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..172
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   COILED          96..128
FT                   /evidence="ECO:0000255"
FT   VARIANT         36
FT                   /note="T -> M (in dbSNP:rs10037031)"
FT                   /id="VAR_057736"
SQ   SEQUENCE   172 AA;  20025 MW;  40CB2BCB063CB240 CRC64;
     MATQQVDSRR QVAAEQVAAQ LLERRRGSHC DDEKQTLLAL LILVLYLSTE IWGSSWEVSE
     RIRECNYYQN LAVPQGLEYQ TNEPSEEPIK TIRNWLKEKL HVFSEKLEEE VQQLEQLAWD
     LELWLDALLG EPHQEEHCST YKSHLWEWAW ALGREHKGGE GLLEISLSGA EL