SIM23_MOUSE
ID SIM23_MOUSE Reviewed; 136 AA.
AC Q9DAL0;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Small integral membrane protein 23;
GN Name=Smim23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK005748; BAB24220.1; -; mRNA.
DR EMBL; AL669951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48767.1; -.
DR RefSeq; NP_081326.1; NM_027050.1.
DR AlphaFoldDB; Q9DAL0; -.
DR SMR; Q9DAL0; -.
DR STRING; 10090.ENSMUSP00000020508; -.
DR PaxDb; Q9DAL0; -.
DR PRIDE; Q9DAL0; -.
DR ProteomicsDB; 261234; -.
DR Antibodypedia; 64430; 3 antibodies from 3 providers.
DR Ensembl; ENSMUST00000020508; ENSMUSP00000020508; ENSMUSG00000020270.
DR GeneID; 69351; -.
DR KEGG; mmu:69351; -.
DR UCSC; uc007ikb.2; mouse.
DR CTD; 644994; -.
DR MGI; MGI:1916601; Smim23.
DR VEuPathDB; HostDB:ENSMUSG00000020270; -.
DR eggNOG; ENOG502TDUM; Eukaryota.
DR GeneTree; ENSGT00390000017300; -.
DR HOGENOM; CLU_155321_0_0_1; -.
DR InParanoid; Q9DAL0; -.
DR OMA; CEDKKQT; -.
DR OrthoDB; 1592023at2759; -.
DR TreeFam; TF338699; -.
DR BioGRID-ORCS; 69351; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Smim23; mouse.
DR PRO; PR:Q9DAL0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DAL0; protein.
DR Bgee; ENSMUSG00000020270; Expressed in spermatid and 15 other tissues.
DR ExpressionAtlas; Q9DAL0; baseline and differential.
DR Genevisible; Q9DAL0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027880; DUF4635.
DR PANTHER; PTHR37865; PTHR37865; 1.
DR Pfam; PF15466; DUF4635; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..136
FT /note="Small integral membrane protein 23"
FT /id="PRO_0000341238"
FT TOPO_DOM 1..31
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..136
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT COILED 92..124
FT /evidence="ECO:0000255"
SQ SEQUENCE 136 AA; 15821 MW; A9F58AF38643284E CRC64;
MTIQKTGCRG REAAEVVEQR RRSHHCDDRK QTLLALLILV LYLGMGISGS SWEVSGQTKD
CNHFQNPVTP QGFEYQTKEP AEEPLRTLRK WLKINLHGFL EKLEKEVREL EQLVRDLEFW
LDALLGDLRP EDPCFT
