SIM24_HUMAN
ID SIM24_HUMAN Reviewed; 130 AA.
AC O75264; B9EJF4; Q9P059;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Small integral membrane protein 24;
DE Flags: Precursor;
GN Name=SMIM24; Synonyms=C19orf77; ORFNames=HSPC323;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-130.
RC TISSUE=Umbilical cord blood;
RA Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L.,
RA Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.;
RT "Human partial CDS from CD34+ stem cells.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC33194.1; Type=Erroneous gene model prediction; Note=Wrong choice of frame and superfluous exons were predicted.; Evidence={ECO:0000305};
CC Sequence=AAF29001.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=EAW69320.1; Type=Erroneous gene model prediction; Note=Wrong choice of frame and superfluous exons were predicted.; Evidence={ECO:0000305};
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DR EMBL; AC005551; AAC33194.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471139; EAW69320.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC146979; AAI46980.1; -; mRNA.
DR EMBL; BC146984; AAI46985.1; -; mRNA.
DR EMBL; AF161441; AAF29001.1; ALT_FRAME; mRNA.
DR CCDS; CCDS45915.1; -.
DR RefSeq; NP_001129975.1; NM_001136503.1.
DR AlphaFoldDB; O75264; -.
DR SMR; O75264; -.
DR BioGRID; 129871; 1.
DR IntAct; O75264; 1.
DR STRING; 9606.ENSP00000215531; -.
DR iPTMnet; O75264; -.
DR PhosphoSitePlus; O75264; -.
DR BioMuta; SMIM24; -.
DR EPD; O75264; -.
DR jPOST; O75264; -.
DR MassIVE; O75264; -.
DR MaxQB; O75264; -.
DR PaxDb; O75264; -.
DR PeptideAtlas; O75264; -.
DR PRIDE; O75264; -.
DR ProteomicsDB; 49874; -.
DR Antibodypedia; 52539; 14 antibodies from 6 providers.
DR DNASU; 284422; -.
DR Ensembl; ENST00000215531.6; ENSP00000215531.4; ENSG00000095932.7.
DR GeneID; 284422; -.
DR KEGG; hsa:284422; -.
DR MANE-Select; ENST00000215531.6; ENSP00000215531.4; NM_001136503.2; NP_001129975.1.
DR UCSC; uc010xhk.2; human.
DR CTD; 284422; -.
DR GeneCards; SMIM24; -.
DR HGNC; HGNC:37244; SMIM24.
DR HPA; ENSG00000095932; Group enriched (epididymis, intestine, kidney).
DR neXtProt; NX_O75264; -.
DR OpenTargets; ENSG00000095932; -.
DR PharmGKB; PA165393200; -.
DR VEuPathDB; HostDB:ENSG00000095932; -.
DR eggNOG; ENOG502SFX1; Eukaryota.
DR GeneTree; ENSGT00940000154660; -.
DR HOGENOM; CLU_170453_0_0_1; -.
DR InParanoid; O75264; -.
DR OMA; ERPKNTA; -.
DR OrthoDB; 1595006at2759; -.
DR PhylomeDB; O75264; -.
DR TreeFam; TF328829; -.
DR PathwayCommons; O75264; -.
DR SignaLink; O75264; -.
DR BioGRID-ORCS; 284422; 9 hits in 1075 CRISPR screens.
DR GenomeRNAi; 284422; -.
DR Pharos; O75264; Tdark.
DR PRO; PR:O75264; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O75264; protein.
DR Bgee; ENSG00000095932; Expressed in kidney epithelium and 147 other tissues.
DR ExpressionAtlas; O75264; baseline and differential.
DR Genevisible; O75264; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031627; PDZK1IP1/SMIM24.
DR PANTHER; PTHR15296; PTHR15296; 1.
DR Pfam; PF15807; MAP17; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..130
FT /note="Small integral membrane protein 24"
FT /id="PRO_0000322598"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 62..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 22
FT /note="Q -> A (in Ref. 4; AAF29001)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="E -> G (in Ref. 4; AAF29001)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 14964 MW; 678E332E2A13BCC7 CRC64;
METLGALLVL EFLLLSPVEA QQATEHRLKP WLVGLAAVVG FLFIVYLVLL ANRLWCSKAR
AEDEEETTFR MESNLYQDQS EDKREKKEAK EKEEKRKKEK KTAKEGESNL GLDLEEKEPG
DHERAKSTVM
