SIM24_MOUSE
ID SIM24_MOUSE Reviewed; 120 AA.
AC Q0VG18;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Small integral membrane protein 24;
DE Flags: Precursor;
GN Name=Smim24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-110, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; BC117023; AAI17024.1; -; mRNA.
DR EMBL; BC117027; AAI17028.1; -; mRNA.
DR CCDS; CCDS35998.1; -.
DR RefSeq; NP_001093387.1; NM_001099917.1.
DR AlphaFoldDB; Q0VG18; -.
DR SMR; Q0VG18; -.
DR STRING; 10090.ENSMUSP00000100959; -.
DR iPTMnet; Q0VG18; -.
DR PhosphoSitePlus; Q0VG18; -.
DR MaxQB; Q0VG18; -.
DR PaxDb; Q0VG18; -.
DR PRIDE; Q0VG18; -.
DR ProteomicsDB; 261045; -.
DR Antibodypedia; 52539; 14 antibodies from 6 providers.
DR Ensembl; ENSMUST00000105322; ENSMUSP00000100959; ENSMUSG00000078439.
DR GeneID; 72273; -.
DR KEGG; mmu:72273; -.
DR UCSC; uc007ghw.1; mouse.
DR CTD; 284422; -.
DR MGI; MGI:1919523; Smim24.
DR VEuPathDB; HostDB:ENSMUSG00000078439; -.
DR eggNOG; ENOG502SFX1; Eukaryota.
DR GeneTree; ENSGT00940000154660; -.
DR HOGENOM; CLU_170453_0_0_1; -.
DR InParanoid; Q0VG18; -.
DR OMA; ERPKNTA; -.
DR OrthoDB; 1600485at2759; -.
DR PhylomeDB; Q0VG18; -.
DR TreeFam; TF328829; -.
DR BioGRID-ORCS; 72273; 0 hits in 74 CRISPR screens.
DR PRO; PR:Q0VG18; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q0VG18; protein.
DR Bgee; ENSMUSG00000078439; Expressed in duodenum and 67 other tissues.
DR ExpressionAtlas; Q0VG18; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031627; PDZK1IP1/SMIM24.
DR PANTHER; PTHR15296; PTHR15296; 1.
DR Pfam; PF15807; MAP17; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..120
FT /note="Small integral membrane protein 24"
FT /id="PRO_0000322599"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 71..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 109
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 120 AA; 13547 MW; 851EE8FF548F8C2F CRC64;
MDTLGRLLLL ATLFLTPAEA QQASERRLKP WLVGLAAVVG FLFIVFILML ANRVWCAKGR
AEDEEATFRM EHIMNENSQP SKADKKQKKK VDRKGGQSNE ALELEEKESS DEERGKKTAL
