ID   SIM27_HUMAN             Reviewed;          55 AA.
AC   A0A1B0GUW7;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Small integral membrane protein 27 {ECO:0000305};
DE   AltName: Full=TOPORS antisense RNA 1 {ECO:0000305};
GN   Name=SMIM27 {ECO:0000312|HGNC:HGNC:31420};
GN   Synonyms=C9orf133 {ECO:0000312|HGNC:HGNC:31420},
GN   TOPORS-AS1 {ECO:0000312|HGNC:HGNC:31420};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AI247328; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL353671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS87647.1; -.
DR   AlphaFoldDB; A0A1B0GUW7; -.
DR   SMR; A0A1B0GUW7; -.
DR   BioMuta; SMIM27; -.
DR   PeptideAtlas; A0A1B0GUW7; -.
DR   Ensembl; ENST00000450093.3; ENSP00000490727.2; ENSG00000235453.12.
DR   Ensembl; ENST00000453396.5; ENSP00000490275.1; ENSG00000235453.12.
DR   Ensembl; ENST00000692500.1; ENSP00000508648.1; ENSG00000235453.12.
DR   MANE-Select; ENST00000692500.1; ENSP00000508648.1; NM_001387564.1; NP_001374493.1.
DR   GeneCards; SMIM27; -.
DR   HGNC; HGNC:31420; SMIM27.
DR   HPA; ENSG00000235453; Low tissue specificity.
DR   neXtProt; NX_A0A1B0GUW7; -.
DR   OpenTargets; ENSG00000235453; -.
DR   VEuPathDB; HostDB:ENSG00000235453; -.
DR   GeneTree; ENSGT01020000230598; -.
DR   OMA; WIYSMLL; -.
DR   SignaLink; A0A1B0GUW7; -.
DR   ChiTaRS; TOPORS-AS1; human.
DR   Pharos; A0A1B0GUW7; Tdark.
DR   PRO; PR:A0A1B0GUW7; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000235453; Expressed in left testis and 185 other tissues.
DR   ExpressionAtlas; A0A1B0GUW7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..55
FT                   /note="Small integral membrane protein 27"
FT                   /id="PRO_0000443388"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   55 AA;  6429 MW;  491DAD4DEE97C723 CRC64;
     MKPVSRRTLD WIYSVLLLAI VLISWGCIIY ASMVSARRQL RKKYPDKIFG TNENL