ID   SIM31_HUMAN             Reviewed;          71 AA.
AC   A0A1B0GVY4;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Small integral membrane protein 31 {ECO:0000305};
GN   Name=SMIM31 {ECO:0000312|HGNC:HGNC:49638};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC104620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC062791; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS87279.1; -.
DR   AlphaFoldDB; A0A1B0GVY4; -.
DR   SMR; A0A1B0GVY4; -.
DR   GlyGen; A0A1B0GVY4; 1 site.
DR   BioMuta; SMIM31; -.
DR   Ensembl; ENST00000507311.1; ENSP00000490699.1; ENSG00000248771.5.
DR   Ensembl; ENST00000515485.5; ENSP00000493952.1; ENSG00000248771.5.
DR   MANE-Select; ENST00000507311.1; ENSP00000490699.1; NM_001352885.1; NP_001339814.1.
DR   GeneCards; SMIM31; -.
DR   HGNC; HGNC:49638; SMIM31.
DR   HPA; ENSG00000248771; Tissue enhanced (gallbladder, intestine, prostate).
DR   neXtProt; NX_A0A1B0GVY4; -.
DR   OpenTargets; ENSG00000248771; -.
DR   VEuPathDB; HostDB:ENSG00000248771; -.
DR   GeneTree; ENSGT00770000121728; -.
DR   OMA; FTNLEMA; -.
DR   Pharos; A0A1B0GVY4; Tdark.
DR   PRO; PR:A0A1B0GVY4; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; A0A1B0GVY4; protein.
DR   Bgee; ENSG00000248771; Expressed in pancreatic ductal cell and 58 other tissues.
DR   GO; GO:0030424; C:axon; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..71
FT                   /note="Small integral membrane protein 31"
FT                   /id="PRO_0000443390"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          31..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CONFLICT        17
FT                   /note="F -> L (in Ref. 2; BC062791)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   71 AA;  8394 MW;  0980B15CB7A60D3A CRC64;
     MELPYTNLEM AFILLAFVIF SLFTLASIYT TPDDSNEEEE HEKKGREKKR KKSEKKKNCS
     EEEHRIEAVE L