ID   SIM33_HUMAN             Reviewed;         132 AA.
AC   A0A1B0GW64;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Small integral membrane protein 33 {ECO:0000305};
GN   Name=SMIM33 {ECO:0000312|HGNC:HGNC:53645};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC138517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0GW64; -.
DR   GlyGen; A0A1B0GW64; 1 site.
DR   BioMuta; ENSG00000283288; -.
DR   PeptideAtlas; A0A1B0GW64; -.
DR   Ensembl; ENST00000637503.2; ENSP00000490796.1; ENSG00000283288.2.
DR   Ensembl; ENST00000671802.1; ENSP00000500347.1; ENSG00000288274.1.
DR   MANE-Select; ENST00000637503.2; ENSP00000490796.1; NM_001365197.1; NP_001352126.1.
DR   GeneCards; SMIM33; -.
DR   HGNC; HGNC:53645; SMIM33.
DR   HPA; ENSG00000283288; Tissue enhanced (intestine, salivary gland).
DR   neXtProt; NX_A0A1B0GW64; -.
DR   OpenTargets; ENSG00000283288; -.
DR   VEuPathDB; HostDB:ENSG00000283288; -.
DR   GeneTree; ENSGT00390000006836; -.
DR   OMA; PRLHQGH; -.
DR   OrthoDB; 1617846at2759; -.
DR   Pharos; A0A1B0GW64; Tdark.
DR   PRO; PR:A0A1B0GW64; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A0A1B0GW64; protein.
DR   Bgee; ENSG00000283288; Expressed in mucosa of transverse colon and 14 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038803; SMIM33.
DR   PANTHER; PTHR37873; PTHR37873; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..132
FT                   /note="Small integral membrane protein 33"
FT                   /id="PRO_0000443399"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..120
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        15
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  14123 MW;  A1FE0F666C56414B CRC64;
     MHQAGHYSWP SPAVNSSSEQ EPQRQLPEVL SGTWEQPRVD GLPVVTVIVA VFVLLAVCII
     VAVHFGPRLH QGHATLPTEP PTPKPDGGIY LIHWRVLGPQ DSPEEAPPGP LVPGSCPAPD
     GPRPSIDEVT CL