SIM43_HUMAN
ID SIM43_HUMAN Reviewed; 63 AA.
AC Q4W5P6; A0A2R8YEN4; D3DNW9; Q96NI2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-OCT-2020, sequence version 4.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Small integral membrane protein 43 {ECO:0000312|HGNC:HGNC:55077};
GN Name=SMIM43 {ECO:0000312|HGNC:HGNC:55077}; Synonyms=TMEM155 {ECO:0000305};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- CAUTION: This was previously named TMEM55 and corresponded to a 130-
CC residue protein. However, recent evidence suggests that the wrong ORF
CC was originally chosen for this protein and supports an upstream ORF
CC coding for a 63-residue protein. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47657.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=AAY40967.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=EAX05253.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=EAX05254.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AC079341; AAY40967.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471056; EAX05253.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471056; EAX05254.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC047657; AAH47657.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001304766.1; NM_001317837.1.
DR RefSeq; NP_001304767.1; NM_001317838.1.
DR RefSeq; NP_001304768.1; NM_001317839.1.
DR RefSeq; NP_001304770.1; NM_001317841.1.
DR RefSeq; NP_001304771.1; NM_001317842.1.
DR RefSeq; NP_689612.3; NM_152399.3.
DR RefSeq; XP_005262794.1; XM_005262737.2.
DR RefSeq; XP_016863214.1; XM_017007725.1.
DR AlphaFoldDB; Q4W5P6; -.
DR SMR; Q4W5P6; -.
DR BioGRID; 126320; 3.
DR IntAct; Q4W5P6; 1.
DR STRING; 9606.ENSP00000336987; -.
DR BioMuta; TMEM155; -.
DR PaxDb; Q4W5P6; -.
DR PeptideAtlas; Q4W5P6; -.
DR PRIDE; Q4W5P6; -.
DR Antibodypedia; 77843; 4 antibodies from 4 providers.
DR DNASU; 132332; -.
DR Ensembl; ENST00000643663.2; ENSP00000495936.2; ENSG00000164112.14.
DR Ensembl; ENST00000643802.2; ENSP00000495721.1; ENSG00000164112.14.
DR GeneID; 132332; -.
DR MANE-Select; ENST00000643802.2; ENSP00000495721.1; NM_001384332.1; NP_001371261.1.
DR UCSC; uc003idx.2; human.
DR CTD; 132332; -.
DR DisGeNET; 132332; -.
DR GeneCards; SMIM43; -.
DR HGNC; HGNC:55077; SMIM43.
DR HPA; ENSG00000164112; Tissue enriched (brain).
DR neXtProt; NX_Q4W5P6; -.
DR OpenTargets; ENSG00000164112; -.
DR VEuPathDB; HostDB:ENSG00000164112; -.
DR eggNOG; ENOG502R363; Eukaryota.
DR GeneTree; ENSGT01010000222815; -.
DR HOGENOM; CLU_160786_0_0_1; -.
DR InParanoid; Q4W5P6; -.
DR OrthoDB; 1347616at2759; -.
DR PhylomeDB; Q4W5P6; -.
DR TreeFam; TF342440; -.
DR PathwayCommons; Q4W5P6; -.
DR SignaLink; Q4W5P6; -.
DR BioGRID-ORCS; 132332; 13 hits in 1038 CRISPR screens.
DR GenomeRNAi; 132332; -.
DR Pharos; Q4W5P6; Tdark.
DR PRO; PR:Q4W5P6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q4W5P6; protein.
DR Bgee; ENSG00000164112; Expressed in Brodmann (1909) area 46 and 109 other tissues.
DR Genevisible; Q4W5P6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..63
FT /note="Small integral membrane protein 43"
FT /id="PRO_0000282437"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 52
FT /note="R -> H (in Ref. 3; AAH47657)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 63 AA; 7323 MW; C6A0987609BE8525 CRC64;
MEWELNLLLY LALFFFLLFL LFLLLFVVIK QLKNSVANTA GALQPGRLSV HREPWGFSRE
QAV
