SIMC1_RAT
ID SIMC1_RAT Reviewed; 1266 AA.
AC F1LWT0;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 3.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=SUMO-interacting motif-containing protein 1;
DE AltName: Full=Platform element for inhibition of autolytic degradation {ECO:0000250|UniProtKB:Q8NDZ2};
GN Name=Simc1; Synonyms=Pleiad {ECO:0000250|UniProtKB:Q8NDZ2};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
CC -!- FUNCTION: Inhibits the protease activity of CAPN3.
CC {ECO:0000250|UniProtKB:Q8NDZ2}.
CC -!- SUBUNIT: Interacts (via SIM domains) with SUMO1 and SUMO2. Interacts
CC with CAPN3 and CTBP1. {ECO:0000250|UniProtKB:Q8NDZ2}.
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DR EMBL; AABR07027009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR07027010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F1LWT0; -.
DR STRING; 10116.ENSRNOP00000060156; -.
DR PaxDb; F1LWT0; -.
DR RGD; 2319689; Simc1.
DR VEuPathDB; HostDB:ENSRNOG00000016932; -.
DR eggNOG; ENOG502RR6K; Eukaryota.
DR HOGENOM; CLU_264356_0_0_1; -.
DR InParanoid; F1LWT0; -.
DR OMA; GDAIQSP; -.
DR TreeFam; TF332523; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000016932; Expressed in testis and 19 other tissues.
DR ExpressionAtlas; F1LWT0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0030017; C:sarcomere; ISS:UniProtKB.
DR GO; GO:0030414; F:peptidase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0032184; F:SUMO polymer binding; ISO:RGD.
DR GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Protease inhibitor; Reference proteome.
FT CHAIN 1..1266
FT /note="SUMO-interacting motif-containing protein 1"
FT /id="PRO_0000451960"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..1266
FT /note="Required for inhibition of CAPN3 protease activity"
FT /evidence="ECO:0000250|UniProtKB:Q8NDZ2"
FT REGION 1024..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 45..49
FT /note="SUMO interaction motif 1 (SIM); mediates the binding
FT to polysumoylated substrates"
FT /evidence="ECO:0000250|UniProtKB:Q8NDZ2"
FT MOTIF 64..68
FT /note="SUMO interaction motif 2 (SIM); mediates the binding
FT to polysumoylated substrates"
FT /evidence="ECO:0000250|UniProtKB:Q8NDZ2"
FT COMPBIAS 532..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1266 AA; 136789 MW; D41D7F60905C4BF5 CRC64;
MEDFIVISDD SGSESSAGTR SGRARRLRRA LSRTPGALPR RTVDFIDLTR ETRTRAKDRN
GLCVIDLTRS EEENRPIATL DLTLEPVASS QKEPPSLQTC TNLSGKEMIE AQGDRGTQPA
AQRVINNDPV DLDLLEENMF EGSRPPTSIS QDSVYPPEPN CSSITYKGDL SFLTSLQLSS
DVSPFSSTSN NSSSSSNQRT SLPCPQQDVP CQSQGLLCSL QALSYPLRGS PCPPRASSCP
PQALSCPPQA LSSLSCPSQT VQCQLQALPQ PPQEVPCSTQ NVPCPQQNIP STPQDLPWHP
RHPLYPSQDT LGLPQDVPGR PQNVSYPQDM TQLQDMPWSL QDMPLSLQDV LQSLQDVPPL
LGDVPQSPEV MQLPGYMTQS SRNVIQSSAG VIRSSGGVMQ PSGCMMQPSG GVTQSLRSAI
QSSGGVMQSS GVTQSLRSVM QSSGGVMQSS GVTQSSGGVT WSLRSVMQSS GCMMQSPGGV
MLSAGDMMQS SGGATRSLRS MMQSSGCMMQ SPGGVTQSSG SVMQSLRNVI QSSGGVTQSS
GGVIQSSSGV PQSLRDRMQS PGSVSQSSGD VIQSPRGASP ASGDVIKSQG GMPRSLRDRM
QSPGGVPQSS EDVIQSAGGV SPASGDAIQS PGGVSPASGD AMQSSGGVTP SLGDVPQSSG
GVSPASGDAM QSPGGVTPSL GDAMQSPGGV SPASGDAMQS PGGVSPSLGD VPQSPGNMLE
SLGNTPNLSG DVSHVPQELL DLAKGRPKLS LNAVQNRHSP MTISAPSSPS CSANPLSQQS
EFSSEKRPWL TVSNSSAREE RSLPQSATPG SAQIQGQIAQ AGVYNRPCLH RLKYFLRPPV
HHLFFQTLIP DKDTRESKGQ KLEPIPHRRL RMVTNTIEEN FPLGTVQFLM DFVSPQHYPP
REIVAHIIQK ILLSGSETVD VLKEAYMLLM KIQQLHPANA KTVEWDWKLL TYVMEEEGQT
LPGRVLFLRY VVQTLEDDFQ QILRRQRQHL QQSIANTVLS CDKQPHNVRD VIKWLVKAVT
ENALTPPQDE TQTSPGPGVL KTSSDHLSPQ PNLARNTNQL IVCQLQRMLS IAVEVDRTPT
CSSNKIAEMM FGFVLDIPER SQREMFFTTM ESHLLRCKVL EIIFLHSCET PTRLPLSLAQ
ALYFLNNSTS LLKCQSDKSQ WQTWDELVEH LQFLLSSYQH VLREHLRSSV IDRKDLIIKR
IKPKPQQGDD ITVVDVEKQI EAFRSRLVHI LGEPLVPQLQ DKVHLLKLLL FYAADLNPDT
EPASER
