SIN1_CAEEL
ID SIN1_CAEEL Reviewed; 642 AA.
AC Q9NA80;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Stress-activated map kinase-interacting protein 1 homolog;
GN Name=sinh-1; ORFNames=Y57A10A.20;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: May interact with a MAP kinase. May act on Ras-regulated
CC pathways (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIN1 family. {ECO:0000305}.
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DR EMBL; BX284602; CAB55023.3; -; Genomic_DNA.
DR PIR; T31640; T31640.
DR RefSeq; NP_496596.3; NM_064195.3.
DR AlphaFoldDB; Q9NA80; -.
DR SMR; Q9NA80; -.
DR STRING; 6239.Y57A10A.20; -.
DR EPD; Q9NA80; -.
DR PaxDb; Q9NA80; -.
DR PeptideAtlas; Q9NA80; -.
DR PRIDE; Q9NA80; -.
DR EnsemblMetazoa; Y57A10A.20.1; Y57A10A.20.1; WBGene00013261.
DR GeneID; 190339; -.
DR KEGG; cel:CELE_Y57A10A.20; -.
DR UCSC; Y57A10A.20; c. elegans.
DR CTD; 190339; -.
DR WormBase; Y57A10A.20; CE43373; WBGene00013261; sinh-1.
DR eggNOG; KOG3739; Eukaryota.
DR GeneTree; ENSGT00390000000642; -.
DR HOGENOM; CLU_015860_0_0_1; -.
DR InParanoid; Q9NA80; -.
DR OMA; CCYEYAR; -.
DR OrthoDB; 580766at2759; -.
DR Reactome; R-CEL-1257604; PIP3 activates AKT signaling.
DR Reactome; R-CEL-389357; CD28 dependent PI3K/Akt signaling.
DR Reactome; R-CEL-5218920; VEGFR2 mediated vascular permeability.
DR Reactome; R-CEL-6804757; Regulation of TP53 Degradation.
DR PRO; PR:Q9NA80; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00013261; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031932; C:TORC2 complex; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0048382; P:mesendoderm development; IGI:WormBase.
DR GO; GO:0038203; P:TORC2 signaling; IBA:GO_Central.
DR InterPro; IPR031567; CRIM_dom.
DR InterPro; IPR008828; Sin1/Avo1.
DR PANTHER; PTHR13335; PTHR13335; 1.
DR Pfam; PF16978; CRIM; 1.
PE 3: Inferred from homology;
KW Reference proteome; Stress response.
FT CHAIN 1..642
FT /note="Stress-activated map kinase-interacting protein 1
FT homolog"
FT /id="PRO_0000331444"
FT REGION 603..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 72654 MW; 276ADBF942C94B00 CRC64;
MGHVDREDLL NVIRHELRLE DDDGPGLCSR LLLNPDRKCR AGGLPLDFRL KNGDLMDDGD
AGFDDIYEIP LYEEPIHTRT LINDSLALRT AEKIKEEGRR DNFYTGPLDE LFVKQEVNWP
PKTPISTEKS AIERYLEENS ANLNNPLGEY SKFAATTTDP SRQIEIIIPM SCDEEIGFKT
LKIEVLTTAR IREVIGYCLL QYYLTFDSYL PGEVDDYQFY LAEEDGEIEH ELPPLDSSKL
VGQVGFTCLG LVSRIKKNGN SRQKRAVAVW FVDKDQYVIE VDNMEKPLRW LRDEAFRLRE
ETVKEREPLF QGLLDIKEYY MEAVDNFDVK LDLEASISSA RSLEFVMIRK NSSRAGFHPR
GGRYGRQMSA MLTLKMPNSP IAAGPMTPLP TVMEESPAVA GTSNGFGFPK AESCGAIAST
PGVTWNDDGG QLSSFIVQRI HKFKPKWKAN LIFRWTCFEI EKYREDRSAF LPQGYQKHTK
VPWEYVGGVR TQLKDAKAGR VDMWQITFFW LPVLSDETVK DVIGDAEWNL NLVAKIYANE
EKWRSVTLET FFKQDVDEIF SQTNSILQAR DASIYKAFSH SSFGTLSPAA SADLALMESA
EAIVSPSSDA PSRSSNGKNG GKFRKMSSLM ASVMGRRKSD SK
