SIN1_CHICK
ID SIN1_CHICK Reviewed; 522 AA.
AC Q9W6S3;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Target of rapamycin complex 2 subunit MAPKAP1;
DE Short=TORC2 subunit MAPKAP1;
DE AltName: Full=Mitogen-activated protein kinase 2-associated protein 1;
DE AltName: Full=Stress-activated map kinase-interacting protein 1;
DE Short=SAPK-interacting protein 1;
GN Name=MAPKAP1; Synonyms=SIN1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10428959; DOI=10.1093/emboj/18.15.4210;
RA Wilkinson M.G., Soto Pino T., Tournier S., Buck V., Martin H.,
RA Christiansen J., Wilkinson D.G., Millar J.B.A.;
RT "Sin1: an evolutionarily conserved component of the eukaryotic SAPK
RT pathway.";
RL EMBO J. 18:4210-4221(1999).
CC -!- FUNCTION: Essential component of the TORC2 complex, which plays a
CC critical role in AKT1 'Ser-473' phosphorylation, and may modulate the
CC phosphorylation of PKCA and regulate actin cytoskeleton organization.
CC May interact with a MAP kinase. May act on Ras-regulated pathways (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the target of rapamycin 2 complex (TORC2).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIN1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF153127; AAD34166.1; -; mRNA.
DR RefSeq; NP_990157.1; NM_204826.1.
DR RefSeq; XP_015134805.1; XM_015279319.1.
DR AlphaFoldDB; Q9W6S3; -.
DR SMR; Q9W6S3; -.
DR STRING; 9031.ENSGALP00000001441; -.
DR PaxDb; Q9W6S3; -.
DR Ensembl; ENSGALT00000001443; ENSGALP00000001441; ENSGALG00000000977.
DR Ensembl; ENSGALT00000094762; ENSGALP00000066582; ENSGALG00000000977.
DR GeneID; 395627; -.
DR KEGG; gga:395627; -.
DR CTD; 79109; -.
DR VEuPathDB; HostDB:geneid_395627; -.
DR eggNOG; KOG3739; Eukaryota.
DR GeneTree; ENSGT00390000000642; -.
DR HOGENOM; CLU_514767_0_0_1; -.
DR InParanoid; Q9W6S3; -.
DR OMA; NAKFWPQ; -.
DR OrthoDB; 1492466at2759; -.
DR PhylomeDB; Q9W6S3; -.
DR TreeFam; TF315174; -.
DR Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-GGA-389357; CD28 dependent PI3K/Akt signaling.
DR Reactome; R-GGA-5218920; VEGFR2 mediated vascular permeability.
DR Reactome; R-GGA-6804757; Regulation of TP53 Degradation.
DR PRO; PR:Q9W6S3; -.
DR Proteomes; UP000000539; Chromosome 17.
DR Bgee; ENSGALG00000000977; Expressed in skeletal muscle tissue and 12 other tissues.
DR ExpressionAtlas; Q9W6S3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031932; C:TORC2 complex; IBA:GO_Central.
DR GO; GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:1900407; P:regulation of cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0038203; P:TORC2 signaling; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR031567; CRIM_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008828; Sin1/Avo1.
DR InterPro; IPR032679; Sin1_N.
DR InterPro; IPR031313; Sin1_PH_dom.
DR PANTHER; PTHR13335; PTHR13335; 1.
DR Pfam; PF16978; CRIM; 1.
DR Pfam; PF05422; SIN1; 1.
DR Pfam; PF16979; SIN1_PH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..522
FT /note="Target of rapamycin complex 2 subunit MAPKAP1"
FT /id="PRO_0000218769"
FT REGION 43..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 59221 MW; 492B220478FF95AB CRC64;
MAFLDNPTII LAHIRQSHVT SDDTGMCEMV LIDHDVDLEK FNPSSTYGDS ASETQGSNGE
TQGYVYSQSV DITSSWDFGI RRRSNTAQRL ERLRKERQNQ IKCKNVQWKD RNTSYSAEEL
SSLFEKKNFR VRSPCSGKQS ILSVRLEQCP LQLNNPFNEY SKFDGKGHVG TTATKKIDVY
LPLHANQDKL QPMTVVTIAN AKVHDLIGLI CWQYTSEGRE PKLNDNVSAY CLHIAEDDGE
VDTDFPPLDS NEPIHKFGFS TLALVEKYSS PGLAAKQSLF VRINAAHGFS LIQVDSMKVT
MKDILQKALK RRKGSQRGSG PQYRLEKQSE PNVPVDLDCT LESQSTLEFC LVRENSSRGE
EISEEDPQID IATVQDMLSS HHYKSFKVSM IHRLRFTTDV QLGISGDKVE IDPVTNQKAS
TKFWIKQKPI SIDSELLCAC DLVEEKSPSH AIFKLTYLSN HDYKHLYFES DAATVNEIVL
KVNYILESRA STARAEYFAQ KQRKLNRRTS FSFQKEKKSG QQ
