ID   SIN1_DROPS              Reviewed;         578 AA.
AC   Q291K8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Stress-activated map kinase-interacting protein 1;
DE            Short=SAPK-interacting protein 1;
GN   Name=Sin1; ORFNames=GA10075;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of a multiprotein complex that phosphorylates Akt1,
CC       a protein that regulates the balance between cell survival and
CC       apoptosis through a cascade that primarily alters the function of
CC       transcription factors that regulate pro- and antiapoptotic genes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIN1 family. {ECO:0000305}.
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DR   EMBL; CM000071; EAL25104.2; -; Genomic_DNA.
DR   RefSeq; XP_001360529.2; XM_001360492.3.
DR   AlphaFoldDB; Q291K8; -.
DR   SMR; Q291K8; -.
DR   STRING; 7237.FBpp0276855; -.
DR   EnsemblMetazoa; FBtr0278417; FBpp0276855; FBgn0070134.
DR   GeneID; 4803881; -.
DR   KEGG; dpo:Dpse_GA10075; -.
DR   eggNOG; KOG3739; Eukaryota.
DR   HOGENOM; CLU_514767_0_0_1; -.
DR   InParanoid; Q291K8; -.
DR   OMA; NAKFWPQ; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0070134; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0031932; C:TORC2 complex; IEA:EnsemblMetazoa.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:EnsemblMetazoa.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEA:EnsemblMetazoa.
DR   GO; GO:0048813; P:dendrite morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0045887; P:positive regulation of synaptic assembly at neuromuscular junction; IEA:EnsemblMetazoa.
DR   GO; GO:0034063; P:stress granule assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0038203; P:TORC2 signaling; IEA:EnsemblMetazoa.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR031567; CRIM_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008828; Sin1/Avo1.
DR   InterPro; IPR032679; Sin1_N.
DR   InterPro; IPR031313; Sin1_PH_dom.
DR   PANTHER; PTHR13335; PTHR13335; 1.
DR   Pfam; PF16978; CRIM; 1.
DR   Pfam; PF05422; SIN1; 1.
DR   Pfam; PF16979; SIN1_PH; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Reference proteome.
FT   CHAIN           1..578
FT                   /note="Stress-activated map kinase-interacting protein 1"
FT                   /id="PRO_0000331443"
FT   REGION          47..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   578 AA;  65402 MW;  4225FE2258F2279F CRC64;
     MATYSNQHWL LSHIRNSFIS TDDTGMCETV MLSDDMPKHY LRKFNSSAGV ESHRRRPLKP
     PLASALPDRN TRHPDAPMQE VDFMCYPGLD LSDDEEDMST HSFDIQMYPE VGAHRFRSNT
     AQKLEKLDIA KRRAARIKSI NYNEEVQPPE DKDFFMRKEI PNIKPTIPKE KKANDDELSD
     EGVQSMLTEQ LAKSPKQTQN KFIEFARFDG TSQVGMQTKR INVYLNMLPE PDRNYPLKVC
     VLSTAKIQEV IGFVCYKTSL QYPDVPLKSL QHYGLYMTED NDDMEDFPPL DNREPCSKFG
     FSHLTLAERR PLAPVTRVDY PGQLGNKSMT SEDDKATLAD AALRALKNIT LNGGAADPGG
     GAVGGGEGDG DGDDSPHDNV KEYEKRLLNH NDMLEAPMHR SFRLNIIDKR FFKSDVTLGI
     SGERIEIDQY KNAKFWPQKK PVSTPIDLVA HCEIVERRHL KALLRIWLKS NSSSSSLPSG
     CTSAPINASV TTLNTGTGSS SAGIAHSPSS PGNSFGFFMT SNIRFKHYDF DTDTHTAEQI
     NSKLNCILEM RSSELRREFL QQRERKQERQ QVKKQLKL