ID   SIN1_XENLA              Reviewed;         520 AA.
AC   Q7ZYH1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Target of rapamycin complex 2 subunit MAPKAP1;
DE            Short=TORC2 subunit MAPKAP1;
DE   AltName: Full=Mitogen-activated protein kinase 2-associated protein 1;
DE   AltName: Full=Stress-activated map kinase-interacting protein 1;
DE            Short=SAPK-interacting protein 1;
GN   Name=mapkap1; Synonyms=sin1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the TORC2 complex, which plays a
CC       critical role in akt1 'Ser-473' phosphorylation, and may modulate the
CC       phosphorylation of pkca and regulate actin cytoskeleton organization.
CC       May interact with a MAP kinase. May act on Ras-regulated pathways (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the target of rapamycin 2 complex (TORC2).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIN1 family. {ECO:0000305}.
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DR   EMBL; BC043789; AAH43789.1; -; mRNA.
DR   RefSeq; NP_001080466.1; NM_001086997.1.
DR   RefSeq; XP_018084136.1; XM_018228647.1.
DR   AlphaFoldDB; Q7ZYH1; -.
DR   SMR; Q7ZYH1; -.
DR   MaxQB; Q7ZYH1; -.
DR   DNASU; 380158; -.
DR   GeneID; 380158; -.
DR   KEGG; xla:380158; -.
DR   CTD; 380158; -.
DR   Xenbase; XB-GENE-478756; mapkap1.L.
DR   OMA; NAKFWPQ; -.
DR   OrthoDB; 1492466at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 380158; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR031567; CRIM_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008828; Sin1/Avo1.
DR   InterPro; IPR032679; Sin1_N.
DR   InterPro; IPR031313; Sin1_PH_dom.
DR   PANTHER; PTHR13335; PTHR13335; 1.
DR   Pfam; PF16978; CRIM; 1.
DR   Pfam; PF05422; SIN1; 1.
DR   Pfam; PF16979; SIN1_PH; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..520
FT                   /note="Target of rapamycin complex 2 subunit MAPKAP1"
FT                   /id="PRO_0000331441"
FT   REGION          310..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  59223 MW;  AA9FF85BC34EE5A3 CRC64;
     MAFLDNPLII LAHIRQSHVT SDDTGMCEMV LIDHDIDLEK LYQSSVPGEN STQMQSNGGE
     TQGYVYSQSV DITSSWDFGI RRRSNTAQKL ERLRKERQNQ IKCKNVQWKD RNTSHSAEEL
     GSLFERKNFK ERDLNHGKQS ILSVRLEQCP LQLNNPFNEY SKFDGKGHVG TTATKKIDVY
     LSMQTSQDKL LPMTVVTIAN AKVHDLIGLI CWQYTTESRE PKLNDNVDAF CLHIAEDDGE
     VDTDFPPLDS NEPIHKFGFS TLALVEKYSS PGLAAKQSLF VRINAAHGFS LIQVDSTNVT
     MQEILEKALK RRKGSQRNSG PQYRLEKQSQ PNVPVDLDST LESQNSLEFC LVRENSSRGE
     EHPEEETQID IATVQDMLSS HQYKSFKVSM IHRLRFTTDV QLGISGEKVE IDPVTNQKTS
     TKFWIKQKPI SIDSDLLCAC DLAEEKSPSH AMFKVTYLSN HDYKHLYFES DAATVNEIVL
     KVNYILESRA STARADYFAQ KQRKLTRRTS FSFQKEKKTG