ID   SIN1_XENTR              Reviewed;         520 AA.
AC   A4IIM3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Target of rapamycin complex 2 subunit MAPKAP1;
DE            Short=TORC2 subunit MAPKAP1;
DE   AltName: Full=Mitogen-activated protein kinase 2-associated protein 1;
DE   AltName: Full=Stress-activated map kinase-interacting protein 1;
DE            Short=SAPK-interacting protein 1;
GN   Name=mapkap1; Synonyms=sin1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the TORC2 complex, which plays a
CC       critical role in akt1 'Ser-473' phosphorylation, and may modulate the
CC       phosphorylation of pkca and regulate actin cytoskeleton organization.
CC       May interact with a MAP kinase. May act on Ras-regulated pathways (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the target of rapamycin 2 complex (TORC2).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIN1 family. {ECO:0000305}.
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DR   EMBL; BC136078; AAI36079.1; -; mRNA.
DR   RefSeq; NP_001093676.1; NM_001100206.1.
DR   RefSeq; XP_012823294.1; XM_012967840.2.
DR   AlphaFoldDB; A4IIM3; -.
DR   SMR; A4IIM3; -.
DR   STRING; 8364.ENSXETP00000034721; -.
DR   PaxDb; A4IIM3; -.
DR   DNASU; 100101680; -.
DR   GeneID; 100101680; -.
DR   KEGG; xtr:100101680; -.
DR   CTD; 79109; -.
DR   Xenbase; XB-GENE-478752; mapkap1.
DR   eggNOG; KOG3739; Eukaryota.
DR   InParanoid; A4IIM3; -.
DR   OrthoDB; 1492466at2759; -.
DR   Reactome; R-XTR-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-XTR-389357; CD28 dependent PI3K/Akt signaling.
DR   Reactome; R-XTR-5218920; VEGFR2 mediated vascular permeability.
DR   Reactome; R-XTR-6804757; Regulation of TP53 Degradation.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000505; Expressed in skeletal muscle tissue and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031932; C:TORC2 complex; IBA:GO_Central.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR   GO; GO:0038203; P:TORC2 signaling; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR031567; CRIM_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008828; Sin1/Avo1.
DR   InterPro; IPR032679; Sin1_N.
DR   InterPro; IPR031313; Sin1_PH_dom.
DR   PANTHER; PTHR13335; PTHR13335; 1.
DR   Pfam; PF16978; CRIM; 1.
DR   Pfam; PF05422; SIN1; 1.
DR   Pfam; PF16979; SIN1_PH; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..520
FT                   /note="Target of rapamycin complex 2 subunit MAPKAP1"
FT                   /id="PRO_0000331442"
FT   REGION          310..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  59129 MW;  E3F0553FB06F917F CRC64;
     MAFLDNPLII LAHIRQSHVT SDDTGMCEMV LIDHDVDLEK LYQSSVSGEN STQMQSNGGE
     TQGYVYSQSV DITSSWDFGI RRRSNTAQKL ERLRKERQNQ IKCKNVQWKD RNTSHSAEEL
     SSLFERKNFK ERALNQGKQS ILSVRLEQCP LQLNNPFNEY SKFDGKGHVG TTATKKIDVY
     LSMQTSQDKL LPMTVVTIAN AKVHDLIGLI CWQYTTEGRE PKLNDNVDAF CLHIAEDDGE
     VDTDFPPLDS NEPIHKFGFS TLALVEKYSS PGLAAKQSLF VRINAAHGFS LIQVDSTNVT
     MRDILEKALK RRKGSQRNSG PQYRLEKQSQ PNVPVDLDST LENQNSLEFC LVRENSSRGE
     EPPEEETQID IATVQDMLSS HQYKSFKVSM IHRLRFTTDV QLGISGEKVE IDPVTNQKTS
     TKFWIKQKPI SIDSDVLCAC DLAEEKSPSH AMFKVTYLSN HDYKHLYFES DAATVNEIVL
     KVNYILESRA STARADYFAQ KQRKLTRRTS FSFQKEKKPG