SINE3_ARATH
ID SINE3_ARATH Reviewed; 193 AA.
AC Q9C900;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein SINE3 {ECO:0000303|PubMed:24891605};
GN Name=SINE3 {ECO:0000303|PubMed:24891605};
GN OrderedLocusNames=At3g06600 {ECO:0000312|Araport:AT3G06600};
GN ORFNames=F5E6.7 {ECO:0000312|EMBL:AAG51336.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Xiao Y.-L., Underwood B.A., Moskal W.A. Jr., Torian U., Redman J.C.,
RA Wu H.C., Utterback T., Town C.D.;
RT "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT thaliana from 5' and 3' RACE products.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, NOMENCLATURE, SUBCELLULAR LOCATION, AND INTERACTION WITH SINE1
RP AND SINE2.
RX PubMed=24891605; DOI=10.1083/jcb.201401138;
RA Zhou X., Graumann K., Wirthmueller L., Jones J.D., Meier I.;
RT "Identification of unique SUN-interacting nuclear envelope proteins with
RT diverse functions in plants.";
RL J. Cell Biol. 205:677-692(2014).
RN [6]
RP REVIEW.
RX PubMed=25740919; DOI=10.1093/jxb/erv082;
RA Zhou X., Graumann K., Meier I.;
RT "The plant nuclear envelope as a multifunctional platform LINCed by SUN and
RT KASH.";
RL J. Exp. Bot. 66:1649-1659(2015).
CC -!- SUBUNIT: Interacts with SUN1 and SUN2. {ECO:0000269|PubMed:24891605}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:24891605};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- DOMAIN: The KASH domain, which contains a transmembrane domain,
CC mediates the nuclear envelope targeting and is involved in the binding
CC to the SUN proteins. {ECO:0000305|PubMed:24891605}.
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DR EMBL; AC020580; AAG51336.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74420.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74421.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65878.1; -; Genomic_DNA.
DR EMBL; AY600562; AAT68361.1; -; mRNA.
DR EMBL; AY649298; AAT69215.1; -; mRNA.
DR RefSeq; NP_001118593.1; NM_001125121.2.
DR RefSeq; NP_001327815.1; NM_001337666.1.
DR RefSeq; NP_187312.1; NM_111536.3.
DR AlphaFoldDB; Q9C900; -.
DR IntAct; Q9C900; 16.
DR STRING; 3702.AT3G06600.2; -.
DR PaxDb; Q9C900; -.
DR PRIDE; Q9C900; -.
DR ProteomicsDB; 228437; -.
DR EnsemblPlants; AT3G06600.1; AT3G06600.1; AT3G06600.
DR EnsemblPlants; AT3G06600.2; AT3G06600.2; AT3G06600.
DR EnsemblPlants; AT3G06600.3; AT3G06600.3; AT3G06600.
DR GeneID; 819839; -.
DR Gramene; AT3G06600.1; AT3G06600.1; AT3G06600.
DR Gramene; AT3G06600.2; AT3G06600.2; AT3G06600.
DR Gramene; AT3G06600.3; AT3G06600.3; AT3G06600.
DR KEGG; ath:AT3G06600; -.
DR Araport; AT3G06600; -.
DR TAIR; locus:2084334; AT3G06600.
DR eggNOG; ENOG502R7KV; Eukaryota.
DR HOGENOM; CLU_1410599_0_0_1; -.
DR InParanoid; Q9C900; -.
DR OMA; HEERNCL; -.
DR OrthoDB; 1372240at2759; -.
DR PhylomeDB; Q9C900; -.
DR PRO; PR:Q9C900; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9C900; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..193
FT /note="Protein SINE3"
FT /id="PRO_0000441683"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 155..193
FT /note="KASH"
FT /evidence="ECO:0000305|PubMed:24891605"
FT REGION 15..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 190..193
FT /note="Required for nuclear localization"
FT /evidence="ECO:0000269|PubMed:24891605"
SQ SEQUENCE 193 AA; 21284 MW; CDD667C034B25649 CRC64;
MKEIQIPRKS FARSSELGAK RLKDPEMKNR KVTTEKRQIA TFSDVSFEST KDPMDFSPIS
QISGAISDSE AESVIQGSSL DLMSTPEICL PADDSPVSTI TSVEARIDTS STDRIQSIVD
LPASVQSLRG EINELKKLIC SVDNSAEINW VDRVVTVKFR IVLLSFILWA ILAAIVVFFS
SGEERAYRGP LPT
