SINE4_ARATH
ID SINE4_ARATH Reviewed; 157 AA.
AC Q9SW31;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein SINE4 {ECO:0000303|PubMed:24891605};
GN Name=SINE4 {ECO:0000303|PubMed:24891605};
GN OrderedLocusNames=At4g24950 {ECO:0000312|Araport:AT4G24950};
GN ORFNames=F13M23.90 {ECO:0000312|EMBL:CAB36737.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, NOMENCLATURE, SUBCELLULAR LOCATION, AND INTERACTION WITH SINE1
RP AND SINE2.
RX PubMed=24891605; DOI=10.1083/jcb.201401138;
RA Zhou X., Graumann K., Wirthmueller L., Jones J.D., Meier I.;
RT "Identification of unique SUN-interacting nuclear envelope proteins with
RT diverse functions in plants.";
RL J. Cell Biol. 205:677-692(2014).
RN [4]
RP REVIEW.
RX PubMed=25740919; DOI=10.1093/jxb/erv082;
RA Zhou X., Graumann K., Meier I.;
RT "The plant nuclear envelope as a multifunctional platform LINCed by SUN and
RT KASH.";
RL J. Exp. Bot. 66:1649-1659(2015).
CC -!- SUBUNIT: Interacts with SUN1 and SUN2. {ECO:0000269|PubMed:24891605}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:24891605};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- DOMAIN: The KASH domain, which contains a transmembrane domain,
CC mediates the nuclear envelope targeting and is involved in the binding
CC to the SUN proteins. {ECO:0000305|PubMed:24891605}.
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DR EMBL; AL035523; CAB36737.1; -; Genomic_DNA.
DR EMBL; AL161562; CAB79404.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84979.1; -; Genomic_DNA.
DR PIR; T05516; T05516.
DR RefSeq; NP_194225.1; NM_118627.1.
DR AlphaFoldDB; Q9SW31; -.
DR STRING; 3702.AT4G24950.1; -.
DR PaxDb; Q9SW31; -.
DR PRIDE; Q9SW31; -.
DR EnsemblPlants; AT4G24950.1; AT4G24950.1; AT4G24950.
DR GeneID; 828597; -.
DR Gramene; AT4G24950.1; AT4G24950.1; AT4G24950.
DR KEGG; ath:AT4G24950; -.
DR Araport; AT4G24950; -.
DR TAIR; locus:2117298; AT4G24950.
DR eggNOG; ENOG502R1MP; Eukaryota.
DR HOGENOM; CLU_1689121_0_0_1; -.
DR OMA; VSWITVE; -.
DR OrthoDB; 1625565at2759; -.
DR PRO; PR:Q9SW31; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SW31; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..157
FT /note="Protein SINE4"
FT /id="PRO_0000441684"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 104..157
FT /note="KASH"
FT /evidence="ECO:0000305|PubMed:24891605"
FT MOTIF 154..157
FT /note="Required for nuclear localization"
FT /evidence="ECO:0000269|PubMed:24891605"
SQ SEQUENCE 157 AA; 18116 MW; 72AFC01DA157BC3D CRC64;
MEEREESSSH EHLKEKLREL EEEWTAMKTG KNSSAVSWIT VEDALEYVEN SPRNLMLSLQ
HKPKAEMIQE ISPLRRKLFH DSDDDDQTKK TTLLSHSSCW SSNVTSSSDT TKAKKKTTIR
RFVSVTMVLL LSWVLVVLMN HFDHLSMNTQ IITLVPT
