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SINI_BACSU
ID   SINI_BACSU              Reviewed;          57 AA.
AC   P23308;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Protein SinI;
GN   Name=sinI; OrderedLocusNames=BSU24600;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3096962; DOI=10.1128/jb.168.2.860-869.1986;
RA   Gaur N.K., Dubnau E., Smith I.;
RT   "Characterization of a cloned Bacillus subtilis gene that inhibits
RT   sporulation in multiple copies.";
RL   J. Bacteriol. 168:860-869(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   PROTEIN SEQUENCE OF 1-20, AND CHARACTERIZATION.
RX   PubMed=8422983; DOI=10.1101/gad.7.1.139;
RA   Bai U., Mandic-Mulec I., Smith I.;
RT   "SinI modulates the activity of SinR, a developmental switch protein of
RT   Bacillus subtilis, by protein-protein interaction.";
RL   Genes Dev. 7:139-148(1993).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH SINR.
RX   PubMed=9799632; DOI=10.1006/jmbi.1998.2163;
RA   Lewis R.J., Brannigan J.A., Offen W.A., Smith I., Wilkinson A.J.;
RT   "An evolutionary link between sporulation and prophage induction in the
RT   structure of a repressor:anti-repressor complex.";
RL   J. Mol. Biol. 283:907-912(1998).
CC   -!- FUNCTION: Acts as an antagonist to SinR. SinI prevents SinR from
CC       binding to its target sequence on the gene for AprE.
CC   -!- SUBUNIT: Heterodimer with SinR. {ECO:0000269|PubMed:9799632}.
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DR   EMBL; M14112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; D84432; BAA12543.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14391.1; -; Genomic_DNA.
DR   PIR; A25159; A25159.
DR   RefSeq; NP_390340.1; NC_000964.3.
DR   RefSeq; WP_003230187.1; NZ_JNCM01000036.1.
DR   PDB; 1B0N; X-ray; 1.90 A; B=1-57.
DR   PDB; 5TMX; NMR; -; A/B=1-57.
DR   PDBsum; 1B0N; -.
DR   PDBsum; 5TMX; -.
DR   AlphaFoldDB; P23308; -.
DR   BMRB; P23308; -.
DR   SMR; P23308; -.
DR   DIP; DIP-6103N; -.
DR   IntAct; P23308; 1.
DR   MINT; P23308; -.
DR   STRING; 224308.BSU24600; -.
DR   PaxDb; P23308; -.
DR   PRIDE; P23308; -.
DR   EnsemblBacteria; CAB14391; CAB14391; BSU_24600.
DR   GeneID; 938543; -.
DR   KEGG; bsu:BSU24600; -.
DR   PATRIC; fig|224308.179.peg.2678; -.
DR   eggNOG; ENOG5030DBE; Bacteria.
DR   OMA; SSQHIQA; -.
DR   BioCyc; BSUB:BSU24600-MON; -.
DR   EvolutionaryTrace; P23308; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR010981; SinR/SinI_dimer_dom.
DR   InterPro; IPR036281; SinR/SinI_dimer_dom_sf.
DR   Pfam; PF08671; SinI; 1.
DR   SUPFAM; SSF47406; SSF47406; 1.
DR   PROSITE; PS51500; SIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Reference proteome.
FT   CHAIN           1..57
FT                   /note="Protein SinI"
FT                   /id="PRO_0000097763"
FT   DOMAIN          2..40
FT                   /note="Sin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00833"
FT   HELIX           13..24
FT                   /evidence="ECO:0007829|PDB:1B0N"
FT   HELIX           29..38
FT                   /evidence="ECO:0007829|PDB:1B0N"
SQ   SEQUENCE   57 AA;  6602 MW;  B72A89E233CD5491 CRC64;
     MKNAKQEHFE LDQEWVELMV EAKEANISPE EIRKYLLLNK KSAHPGPAAR SHTVNPF
 
 
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