ID   SINR_SALTY              Reviewed;         315 AA.
AC   P37459;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable HTH-type transcriptional regulator SinR;
GN   Name=sinR; OrderedLocusNames=STM0304;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8430070; DOI=10.1073/pnas.90.3.1033;
RA   Groisman E.A., Sturmoski M.A., Solomon F.R., Lin R., Ochman H.;
RT   "Molecular, functional, and evolutionary analysis of sequences specific to
RT   Salmonella.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:1033-1037(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Probable regulatory protein. Its target is not known.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L04307; AAA27226.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL19261.1; -; Genomic_DNA.
DR   PIR; A47269; A47269.
DR   RefSeq; NP_459302.1; NC_003197.2.
DR   RefSeq; WP_000970302.1; NC_003197.2.
DR   AlphaFoldDB; P37459; -.
DR   SMR; P37459; -.
DR   STRING; 99287.STM0304; -.
DR   PaxDb; P37459; -.
DR   DNASU; 1251823; -.
DR   EnsemblBacteria; AAL19261; AAL19261; STM0304.
DR   GeneID; 1251823; -.
DR   KEGG; stm:STM0304; -.
DR   PATRIC; fig|99287.12.peg.323; -.
DR   HOGENOM; CLU_039613_16_2_6; -.
DR   OMA; IGLIRNW; -.
DR   PhylomeDB; P37459; -.
DR   BioCyc; SENT99287:STM0304-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..315
FT                   /note="Probable HTH-type transcriptional regulator SinR"
FT                   /id="PRO_0000105750"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   315 AA;  36324 MW;  5850D262CBD9921C CRC64;
     MMELINNRGM RDWMIFIKVA EVGNLSRAAR ELDISISAVS KSLSRLENSI EVTLLRRDSH
     HLELTGAGQT AYASMKRITS SFQSLLDELR NPDKIIRGSI KFSAPAIVCE FLANKWIWEF
     TASYPDTKIY LDSRERSDFF SKSLEFDELV FKSGIIESED LVYRKISPLK LVLCASPKYI
     RKYGRISHPG DLENHIIVGL HNHGLSGPLT LFRQDESYTI SGAVNVHLSS NNLLSVLNLV
     LEGKGINLMT PAWLATKYLK NNELEIILPE WRVPDLPIYL VWRHRQYYSP LFQRFLSFIE
     DKWNNRPQID FLNDD