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SIP11_ARATH
ID   SIP11_ARATH             Reviewed;         240 AA.
AC   Q9M8W5; Q0WWC3;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Aquaporin SIP1-1;
DE   AltName: Full=Small basic intrinsic protein 1-1;
DE            Short=AtSIP1;1;
GN   Name=SIP1-1; OrderedLocusNames=At3g04090; ORFNames=T6K12.29;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NOMENCLATURE, AND TISSUE SPECIFICITY.
RX   PubMed=11806824; DOI=10.1186/gb-2001-3-1-research0001;
RA   Quigley F., Rosenberg J.M., Shachar-Hill Y., Bohnert H.J.;
RT   "From genome to function: the Arabidopsis aquaporins.";
RL   Genome Biol. 3:RESEARCH0001.1-RESEARCH0001.17(2002).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=16223486; DOI=10.1016/j.febslet.2005.09.076;
RA   Ishikawa F., Suga S., Uemura T., Sato M.H., Maeshima M.;
RT   "Novel type aquaporin SIPs are mainly localized to the ER membrane and show
RT   cell-specific expression in Arabidopsis thaliana.";
RL   FEBS Lett. 579:5814-5820(2005).
CC   -!- FUNCTION: Water channel required to facilitate the transport of water
CC       across cell membrane. {ECO:0000269|PubMed:16223486}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16223486}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:16223486}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots and above ground. Expressed in
CC       elongating regions of the root tips, trichome cells of the rosette
CC       leaves, vascular tissues of the flower petals, stigma, stamens (anthers
CC       and filaments), pollen and the top and bottom (receptacle) of siliques.
CC       {ECO:0000269|PubMed:11806824, ECO:0000269|PubMed:16223486}.
CC   -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC       membrane-spanning domains and a pore-forming loop with the signature
CC       motif Asn-Pro-Ala/Thr (NPA).
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. SIP (TC
CC       1.A.8.10) subfamily. {ECO:0000305}.
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DR   EMBL; AC016829; AAF26804.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74036.1; -; Genomic_DNA.
DR   EMBL; AK226432; BAE98575.1; -; mRNA.
DR   RefSeq; NP_187059.1; NM_111280.5.
DR   AlphaFoldDB; Q9M8W5; -.
DR   SMR; Q9M8W5; -.
DR   STRING; 3702.AT3G04090.1; -.
DR   TCDB; 1.A.8.10.5; the major intrinsic protein (mip) family.
DR   PaxDb; Q9M8W5; -.
DR   PRIDE; Q9M8W5; -.
DR   ProteomicsDB; 234463; -.
DR   EnsemblPlants; AT3G04090.1; AT3G04090.1; AT3G04090.
DR   GeneID; 819564; -.
DR   Gramene; AT3G04090.1; AT3G04090.1; AT3G04090.
DR   KEGG; ath:AT3G04090; -.
DR   Araport; AT3G04090; -.
DR   TAIR; locus:2103010; AT3G04090.
DR   eggNOG; KOG0223; Eukaryota.
DR   HOGENOM; CLU_100006_0_0_1; -.
DR   InParanoid; Q9M8W5; -.
DR   OMA; NPIIKTW; -.
DR   OrthoDB; 1487748at2759; -.
DR   PhylomeDB; Q9M8W5; -.
DR   PRO; PR:Q9M8W5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9M8W5; baseline and differential.
DR   Genevisible; Q9M8W5; AT.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015250; F:water channel activity; IDA:TAIR.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR044222; SIP1-1/2-like.
DR   PANTHER; PTHR46739; PTHR46739; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..240
FT                   /note="Aquaporin SIP1-1"
FT                   /id="PRO_0000064073"
FT   TRANSMEM        13..33
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   MOTIF           70..72
FT                   /note="NPA 1"
FT   MOTIF           185..187
FT                   /note="NPA 2"
SQ   SEQUENCE   240 AA;  25706 MW;  CC0D694AB1DC163A CRC64;
     MMGVLKSAIG DMLMTFSWVV LSATFGIQTA AIISAGDFQA ITWAPLVILT SLIFVYVSIF
     TVIFGSASFN PTGSAAFYVA GVPGDTLFSL AIRLPAQAIG AAGGALAIME FIPEKYKHMI
     GGPSLQVDVH TGAIAETILS FGITFAVLLI ILRGPRRLLA KTFLLALATI SFVVAGSKYT
     GPAMNPAIAF GWAYMYSSHN TWDHIYVYWI SSFVGALSAA LLFRSIFPPP RPQKKKQKKA
 
 
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