ID   SIP1_CAEEL              Reviewed;         159 AA.
AC   Q20363;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Stress-induced protein 1;
GN   Name=sip-1 {ECO:0000312|EMBL:CAA84703.1}; ORFNames=F43D9.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1] {ECO:0000312|EMBL:CAA84703.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 17-52; 57-68; 86-92 AND 98-134, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RA   Bienvenut W.V.;
RL   Submitted (MAR-2006) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; Z35640; CAA84703.1; -; Genomic_DNA.
DR   PIR; T22126; T22126.
DR   RefSeq; NP_499316.1; NM_066915.4.
DR   PDB; 4YDZ; X-ray; 3.60 A; A/B/C/D=1-159.
DR   PDB; 4YE0; X-ray; 2.10 A; A/B=43-159.
DR   PDBsum; 4YDZ; -.
DR   PDBsum; 4YE0; -.
DR   AlphaFoldDB; Q20363; -.
DR   SMR; Q20363; -.
DR   BioGRID; 41662; 10.
DR   IntAct; Q20363; 3.
DR   MINT; Q20363; -.
DR   STRING; 6239.F43D9.4; -.
DR   EPD; Q20363; -.
DR   PaxDb; Q20363; -.
DR   PeptideAtlas; Q20363; -.
DR   EnsemblMetazoa; F43D9.4.1; F43D9.4.1; WBGene00004798.
DR   GeneID; 176471; -.
DR   KEGG; cel:CELE_F43D9.4; -.
DR   UCSC; F43D9.4.1; c. elegans.
DR   CTD; 176471; -.
DR   WormBase; F43D9.4; CE00994; WBGene00004798; sip-1.
DR   eggNOG; KOG3591; Eukaryota.
DR   HOGENOM; CLU_095001_4_1_1; -.
DR   InParanoid; Q20363; -.
DR   OMA; DLAHIHT; -.
DR   OrthoDB; 1187096at2759; -.
DR   PhylomeDB; Q20363; -.
DR   Reactome; R-CEL-3371571; HSF1-dependent transactivation.
DR   SignaLink; Q20363; -.
DR   PRO; PR:Q20363; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00004798; Expressed in germ line (C elegans) and 5 other tissues.
DR   GO; GO:0005829; C:cytosol; IDA:WormBase.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0008340; P:determination of adult lifespan; IGI:WormBase.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0019538; P:protein metabolic process; IEP:WormBase.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IMP:WormBase.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   PANTHER; PTHR45640; PTHR45640; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Reference proteome.
FT   CHAIN           1..159
FT                   /note="Stress-induced protein 1"
FT                   /id="PRO_0000239933"
FT   DOMAIN          33..141
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   STRAND          46..48
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   STRAND          50..58
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   HELIX           64..66
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   STRAND          67..72
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   STRAND          75..85
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   STRAND          87..100
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   HELIX           107..109
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   STRAND          111..114
FT                   /evidence="ECO:0007829|PDB:4YE0"
FT   STRAND          118..126
FT                   /evidence="ECO:0007829|PDB:4YE0"
SQ   SEQUENCE   159 AA;  17839 MW;  92B952775FFA9D53 CRC64;
     MSSLCPYTGR PTGLFRDFED MMPYWAQRHS MLNNFNNIVP QQLNEVENTA QKFCVKLDVA
     AFKPEELKVN LEGHVLTIEG HHEVKTEHGF SKRSFTRQFT LPKDVDLAHI HTVINKEGQM
     TIDAPKTGSN TTVRALPIHT SAGHAVTQKP SSTTTTGKH