ID   SIP21_MAIZE             Reviewed;         249 AA.
AC   Q9ATM1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Aquaporin SIP2-1;
DE   AltName: Full=Small basic intrinsic protein 2-1;
DE   AltName: Full=ZmSIP2-1;
DE   AltName: Full=ZmSIP2;1;
GN   Name=SIP2-1; Synonyms=SIP2A;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. B73;
RX   PubMed=11244102; DOI=10.1104/pp.125.3.1206;
RA   Chaumont F., Barrieu F., Wojcik E., Chrispeels M.J., Jung R.;
RT   "Aquaporins constitute a large and highly divergent protein family in
RT   maize.";
RL   Plant Physiol. 125:1206-1215(2001).
CC   -!- FUNCTION: Aquaporins facilitate the transport of water and small
CC       neutral solutes across cell membranes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC       membrane-spanning domains and a pore-forming loop with the signature
CC       motif Asn-Pro-Ala (NPA).
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. SIP (TC
CC       1.A.8.10) subfamily. {ECO:0000305}.
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DR   EMBL; AF326499; AAK26766.1; -; mRNA.
DR   RefSeq; NP_001105640.1; NM_001112170.1.
DR   AlphaFoldDB; Q9ATM1; -.
DR   SMR; Q9ATM1; -.
DR   STRING; 4577.GRMZM2G175038_P01; -.
DR   PaxDb; Q9ATM1; -.
DR   EnsemblPlants; Zm00001eb015230_T001; Zm00001eb015230_P001; Zm00001eb015230.
DR   GeneID; 542646; -.
DR   Gramene; Zm00001eb015230_T001; Zm00001eb015230_P001; Zm00001eb015230.
DR   KEGG; zma:542646; -.
DR   MaizeGDB; 403437; -.
DR   eggNOG; KOG0223; Eukaryota.
DR   HOGENOM; CLU_100006_0_0_1; -.
DR   OMA; HGGPAVY; -.
DR   OrthoDB; 1080106at2759; -.
DR   Proteomes; UP000007305; Chromosome 1.
DR   ExpressionAtlas; Q9ATM1; baseline and differential.
DR   Genevisible; Q9ATM1; ZM.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblPlants.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   GO; GO:0009846; P:pollen germination; IEA:EnsemblPlants.
DR   GO; GO:0009860; P:pollen tube growth; IEA:EnsemblPlants.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR044226; SIP2-1-like.
DR   PANTHER; PTHR47720; PTHR47720; 1.
DR   Pfam; PF00230; MIP; 1.
DR   SUPFAM; SSF81338; SSF81338; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..249
FT                   /note="Aquaporin SIP2-1"
FT                   /id="PRO_0000286042"
FT   TRANSMEM        12..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..155
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   MOTIF           76..78
FT                   /note="NPA 1"
FT                   /evidence="ECO:0000250"
FT   MOTIF           189..191
FT                   /note="NPA 2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   249 AA;  26751 MW;  21D9D4CCDB6D0111 CRC64;
     MSPAPSRPRI RPWLVVGDLA LAAAWVCAGA LVKLLVYGGL GLGGRPEAEA VKVSLSLVYM
     FLFAWLEAAS GGASYNPLTV LAAALASHGG PAVYLFTAFA RIPAQVIGAV LGVKLIQVTF
     PNVGKGARLS VGAHHGALAE GLATFMVVMV SVTLKKKEMK SFFMKTWITS IWKNTIHLLS
     SDITGGIMNP ASAFAWAYAR GDHTTFDHLL VYWLAPLQAT LLGVWAVTFF TKPKKIKEQK
     VDENKIKKE