SIP4_YEAST
ID SIP4_YEAST Reviewed; 829 AA.
AC P46954; D6VW95;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein SIP4;
GN Name=SIP4; OrderedLocusNames=YJL089W; ORFNames=J0922;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RA Lesage P., Yang X., Carlson M.;
RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7483841; DOI=10.1002/yea.320110709;
RA Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E.,
RA Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.;
RT "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces
RT cerevisiae chromosome X, including putative proteins with leucine zippers,
RT a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-
RT alpha 2 binding site.";
RL Yeast 11:681-689(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Interacts with the SNF1 protein kinase.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; U17643; AAB04119.1; -; Genomic_DNA.
DR EMBL; X83502; CAA58479.1; -; Genomic_DNA.
DR EMBL; Z49364; CAA89382.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08711.1; -; Genomic_DNA.
DR PIR; S50246; S50246.
DR RefSeq; NP_012446.1; NM_001181522.1.
DR AlphaFoldDB; P46954; -.
DR SMR; P46954; -.
DR BioGRID; 33668; 139.
DR DIP; DIP-840N; -.
DR STRING; 4932.YJL089W; -.
DR PaxDb; P46954; -.
DR PRIDE; P46954; -.
DR EnsemblFungi; YJL089W_mRNA; YJL089W; YJL089W.
DR GeneID; 853356; -.
DR KEGG; sce:YJL089W; -.
DR SGD; S000003625; SIP4.
DR VEuPathDB; FungiDB:YJL089W; -.
DR eggNOG; ENOG502QV6Q; Eukaryota.
DR HOGENOM; CLU_011307_0_0_1; -.
DR InParanoid; P46954; -.
DR OMA; RGFPRGY; -.
DR BioCyc; YEAST:G3O-31544-MON; -.
DR PRO; PR:P46954; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P46954; protein.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:2000218; P:negative regulation of invasive growth in response to glucose limitation; IMP:SGD.
DR GO; GO:0045722; P:positive regulation of gluconeogenesis; IPI:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0061414; P:positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source; IMP:SGD.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 4: Predicted;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..829
FT /note="Protein SIP4"
FT /id="PRO_0000114979"
FT DNA_BIND 46..73
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 722..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..736
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 656
FT /note="N -> T (in Ref. 1; AAB04119)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 829 AA; 96005 MW; 5B1185166E55E3F7 CRC64;
MAKRKYGRSY SLDDTDSCSN KVLIVPTGQS SSNAITDFSV RKAHACDRCR LKKIKCDGLK
PNCSNCAKID FPCKTSDKLS RRGLPKGYTE LLEKEVVRLT NMNASSSANA NSNLPFINDT
FYCFDNYNTQ SENQRFLGHL TWNILTNTFP TQKAVVFTDD RNNIDLQLQL LTNFLNLNGD
FNHLPNFLLL KYDYNLQFLK NLLSVIIKDF FKRQNSLLLL LYPTNLWKNL LLDKINSTAM
TGEPITLLAL LYIIQFTWSC FDDFKLFKVT KLIVSLTTNS KLDLKVLQLV NLSIFYFMGA
SVDSCKSKSS LTEHSNVNSV IWTNDLLNLN FTNILNMGLY INPKNLIPIS GNNNNNKSNE
EDDRIVTFWC FQFLSSWWSL IQGLPKSNFL TEEFQPKSIS VLEIPRLKPF EILLNFIIYS
LDGCNLLNIS SLNVSDPNFQ FFQNELESFK KNLLLWNLYH NLSDHDNFRF LTSSSNKKLT
TNLLLKNLTG LNHKLNQPDF VEIQLTLFYL SLKLMTLKEG DQDLKKEDIS LEILSLYFLI
LTDDSNNDDN QQLQPQQLNL YHFTPFNSID IIDLCLNNLN NWSLSLKYES GQNQPHSSKI
KFEKFQNFLN HWCPIWYYDE FSTNPFLQIL KINFKLLPFE TIHYSQEEQR LLISLNKLRY
LDAVSSFNSS SVKSNFASKV NTQLNLLQHS SSNSNFLDAS PYDFNKIFMN NFENYDYETD
EGYAEDDDEE DSDSDNSLPL EIPFKKSKNK CKNRNKELSQ RLSLFENRDS NSVDFNTDTN
LNLNPDSPSV TSSKKKYLDH IILDNRDIVS NHDSSKQKFK IQNILNSTF
