ID   SIP5_AJECN              Reviewed;         824 AA.
AC   A6REV3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Protein SIP5;
GN   Name=SIP5; ORFNames=HCAG_08168;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: May negatively regulate the SNF1 kinase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIP5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDN04502.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476664; EDN04502.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001537059.1; XM_001537009.1.
DR   AlphaFoldDB; A6REV3; -.
DR   STRING; 339724.A6REV3; -.
DR   EnsemblFungi; EDN04502; EDN04502; HCAG_08168.
DR   GeneID; 5443316; -.
DR   KEGG; aje:HCAG_08168; -.
DR   HOGENOM; CLU_009068_1_0_1; -.
DR   OrthoDB; 642531at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039301; Sip5/DA2.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR31315; PTHR31315; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..824
FT                   /note="Protein SIP5"
FT                   /id="PRO_0000333424"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          473..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..535
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        561..591
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        594..618
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        735..750
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        751..765
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        794..809
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        810..824
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  89520 MW;  91A1839EE9C6CC6B CRC64;
     MGNTATKEAR PPAGTSGRNG HGRGPSGGAV ALGGLGRFHN QPESSQPGVS SRHFRGSRPD
     LSFLGIGPAV DRDSFVERKE TKQERDARRL ARERAARIKE RERSMKEEHV DGGYLVTQGV
     YTGVEDFNKA VVRQLMIERR LAPFWKGLEE FSDSWTEHQL MAAARGLLIP APDEIPPELE
     YKLTPPRLPE DQDLPDQNLN NLTVPITSRS QSYNSDLSST THPVSPSISL QPQLSPGVSG
     SPGAHLFRGR AKTLASLTAS SKHSSPGEMS PRELQLPKDP FVNGQPIEAY LYKNPIECPI
     CFLYYPPYLN RTRCCDQWIC SECFVQIKRA DPHLPEHEQR DPNSPSPDRP DGQLISEPAG
     CPFCVQPDFG VSYTPPPFRR GLSYIPSNSL DKTLLSPASS TSSLVSGNAN SHSITTRRRA
     TSLSANSPAV IMTDKIRPDW AHKLQTARAQ AARRSAAATA LHAAAYINAM NNPIETRGMG
     SSSRRMLRRT TGHGSDNSTN QAGSVALLAE RRAIAADREN DSPAESTSNL APARASSRRN
     RMDELEEMMM MEAIRLSLAS EEERRKKEEK EAKKEAKRRE REAKRAEKLA RKNGLYSNNP
     SSVALDATGS NTAVRTGREL SPPVSVLEPS SDKGKAVDRP GSLSEPPHTD TQLPGLPKLS
     LKTSDDDLSS IFAPSSAAAA KRSHLRHISS SSSSNSSLVG SACGELIGSG STPNFNSAIE
     PVLNFRSLDA VIDDENTNGS RHEHLEGATK LKKTQQPSND NAISPRPNRD LGLGVEPGSV
     QQATVPPQGD SSINKDENDV RDKELQSHTA ETMHGGNTNL ETVG