ID   SIP5_COCIM              Reviewed;         786 AA.
AC   Q1DZ34; J3KDW3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Protein SIP5;
GN   Name=SIP5; ORFNames=CIMG_04429;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: May negatively regulate the SNF1 kinase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIP5 family. {ECO:0000305}.
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DR   EMBL; GG704914; EAS33405.3; -; Genomic_DNA.
DR   RefSeq; XP_001244988.1; XM_001244987.2.
DR   AlphaFoldDB; Q1DZ34; -.
DR   STRING; 246410.Q1DZ34; -.
DR   EnsemblFungi; EAS33405; EAS33405; CIMG_04429.
DR   GeneID; 4565141; -.
DR   KEGG; cim:CIMG_04429; -.
DR   VEuPathDB; FungiDB:CIMG_04429; -.
DR   InParanoid; Q1DZ34; -.
DR   OMA; VTEPAAC; -.
DR   OrthoDB; 642531at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039301; Sip5/DA2.
DR   PANTHER; PTHR31315; PTHR31315; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..786
FT                   /note="Protein SIP5"
FT                   /id="PRO_0000333435"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          494..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          705..786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..329
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..572
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..603
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..693
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        713..732
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..762
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   786 AA;  84738 MW;  B7F0A53ADBFF8337 CRC64;
     MGNAATKESR SSQEHSARHS RGGSTASTAA YDHYRPSDGI HASSSRALRG GRSDFALLGL
     GAEREPVEHR RETRQEREAR KREKENAARI KERQRSMKEE HVDGGYLVTQ GVYVGTEDFN
     KAIVRQLMIE RRLAPFWRGL NDFSESWTEH QLMAAARGMP IPAPDEVPPE LEYKIPSKSS
     AEKQPPERNL NTLMVPITSR SQSYNSDTSS INRTISPARS PGALSPTNSF LRGRAKTLAS
     LTTSSKTPAS DMAPRELQLP KDPFVNGQPI EAYLYKDASE CPICFLYYPP YLNKTRCCDQ
     PICSECFVQI KRPDPHPPEH HDPNNSETTH PDEPEGQLVS EPAACPFCVQ PEFGVMYTPP
     PFRRGLAYAA SPGVHALANS SAASSASSLV SGGANPGTRR RAVSISADSP SVITTDRVRP
     DWATKLAAAR AQAARRSAAA TALHTAAYMM NNPGGPGEPR RRGMLRRTAG QDSPGGRTAP
     SHVNAMAYLA ERRVVTDRDN ASPVDSTTNL APPRASSRRS RIDELEEMMM MEAIRLSLAA
     EEERRKKEEK ETRKEAKRRE KEAKKAEKSA KKAGLDSQNP SNLTSSTSSA NSAVQTAGGA
     NSELDMSANK GKGVDRSEPR PGVSTEAGSS TEPPKITIKD LKGEQFSSML EGSSKNMHLR
     HVSSASSSNS SLVESAFGES IGSGTPHNGS SSSLAAIHGF RSLAAMIDDT PSGDSGESMN
     RPGSTNEQVQ GAPAVKEPSE NSAPNEPDQV TLLSSSPSLE QKDTLGKEVH MSSAEVLPQS
     SLGTAS