ID   SIP5_NEUCR              Reviewed;         857 AA.
AC   Q7S6X4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Protein sip-5;
GN   Name=sip-5; ORFNames=NCU05589;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: May negatively regulate the snf-1 kinase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIP5 family. {ECO:0000305}.
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DR   EMBL; CM002241; EAA31315.1; -; Genomic_DNA.
DR   RefSeq; XP_960551.1; XM_955458.2.
DR   AlphaFoldDB; Q7S6X4; -.
DR   STRING; 5141.EFNCRP00000005553; -.
DR   EnsemblFungi; EAA31315; EAA31315; NCU05589.
DR   GeneID; 3876713; -.
DR   KEGG; ncr:NCU05589; -.
DR   VEuPathDB; FungiDB:NCU05589; -.
DR   HOGENOM; CLU_009068_1_0_1; -.
DR   InParanoid; Q7S6X4; -.
DR   OMA; CPICFLT; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039301; Sip5/DA2.
DR   PANTHER; PTHR31315; PTHR31315; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..857
FT                   /note="Protein sip-5"
FT                   /id="PRO_0000333439"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          545..747
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          763..857
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..487
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..573
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        609..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..716
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        779..796
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        800..857
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   857 AA;  90234 MW;  FE296AA43A187AA3 CRC64;
     MGNANTKESR GDDSGRRGLH SALDAGIGSS TQSGRESSRR NRNTRHDLTG LLGRAAGGSS
     SHADERHERK ETKQEREARR LEKERVARLQ ERERSMKEEH VDGGYLVTMG TYVGPEDFNK
     QIVRQLMIER KLAPFWRGLN DFDENWTEPQ IIAAARGLPI PAAGETPPDE LIPRPRSPAS
     PTDASSNTNH LTVPIGGRSL STASEHSTSN AGSALPSPGS GKGSSSPFKP TRGKAIAAVL
     GGGSCRNGSS TEIAPREIML PNDPFVNGQP LEVFLYKNAT ECPICFLTYP PYLNHTRCCD
     QPICSECFVQ IKRPDPHFPE GHNENDPNNN PEESAGLLVS EPACCPYCTQ PDFGVTYEPP
     PFRRGLTYAI SPLALGSTSA AMSSESSVNS GSLSPGVASP GGRRRNQSLS ANAPNVVLTD
     KVRPEWATKL QAARAHLARR AAAATALHTA AFLMNNNESR ALRSRFGRRN TGGSGSASAT
     PGNGDENRGT GPATPANAGA TANTDRAAGS SGNGNRRSRL EDLEEMMFAE AIRLSLAAEE
     ERKKKAEKEE QKEAKKREKE REKAEKKAEK AAAKAAAKQG GPYEASRSGH SSASGSSLSL
     PGLSFGRKRG NSAASNLRVE ASVASAMAST GAAMTTPAAP GALAPDSSTK DKGKAVDRSA
     GAASNDASAR PIPSPQPMAG PSHLRQMSSA SSASSSAVES NQGSYVPPSN LQDPRGSGLS
     LGGRSGVSED GDEQDRDPST STEPMFNFRS LAEVVGVSIE GEHAGKRLSQ INADGQAIEG
     EDETAKSGEG AGEHVEHVLD SQTTGISEQD SEINSQPPRL TVTLDSPATS VGDVSTASDS
     KHVGNETTVE HATQVTL