SIP5_SCHPO
ID SIP5_SCHPO Reviewed; 554 AA.
AC O74775;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein sip5;
GN Name=sip5; ORFNames=SPBC25B2.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND THR-128, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: May negatively regulate the snf1 kinase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIP5 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA21261.1; -; Genomic_DNA.
DR PIR; T39979; T39979.
DR RefSeq; NP_596071.1; NM_001021983.2.
DR AlphaFoldDB; O74775; -.
DR BioGRID; 276963; 7.
DR STRING; 4896.SPBC25B2.03.1; -.
DR iPTMnet; O74775; -.
DR MaxQB; O74775; -.
DR PaxDb; O74775; -.
DR PRIDE; O74775; -.
DR EnsemblFungi; SPBC25B2.03.1; SPBC25B2.03.1:pep; SPBC25B2.03.
DR GeneID; 2540435; -.
DR KEGG; spo:SPBC25B2.03; -.
DR PomBase; SPBC25B2.03; -.
DR VEuPathDB; FungiDB:SPBC25B2.03; -.
DR eggNOG; KOG2789; Eukaryota.
DR HOGENOM; CLU_492714_0_0_1; -.
DR InParanoid; O74775; -.
DR OMA; ISEPANC; -.
DR PhylomeDB; O74775; -.
DR PRO; PR:O74775; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0061659; F:ubiquitin-like protein ligase activity; ISM:PomBase.
DR GO; GO:0070647; P:protein modification by small protein conjugation or removal; IC:PomBase.
DR InterPro; IPR039301; Sip5/DA2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR31315; PTHR31315; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..554
FT /note="Protein sip5"
FT /id="PRO_0000333442"
FT REGION 103..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 127
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 128
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 554 AA; 61805 MW; 693E1A73EC0E51FD CRC64;
MGNTIGKERQ ENDEELIQHL VQLVDGGFLD PQGVYSSAPA YKTNIVRKLM LERRLMPFYK
GLDSYSKDWP ADKVVEVVEK ALGPHKSALL HCAIRQSRSL SVGNTRSLKR DSRGSSDHLL
TRNRSNSTPG SISADYRTTA ITTIYANAME CPICFLYYPS NFNYTRCCAQ PICSECFVEI
RRAEPHLPTV HANEPTPNEF DLISEPAKCP YCMTERFGVI YKPNPKLTPF SFNNNPDTLP
SNIAPMGTLS KSSLPLHHIP WPPNQHIKFA HDDKNVVSTD FIHPDWQYKL ERARRRALRR
AANATLLNSH LLETGPANAN ANHNTDLSHD PTSHGGPRRT LSSRRQHYLA NVEQLMLAEA
IRQSLLDAQS NDSTNSLPST EVSQPDSTNI SNEQEIVQPQ PTHTTNVALV EEINRPDSVE
SAITASSSID TGNENETQEV NSDSLPQFVH QTMTQTNFQE SSPSVAADET RVHNVDEYIE
QQDLDELIHS PIASTNPFLA DQFARSETVD LNAHICSPAL SVSDDGVTAT NKTQSSFPSV
YEHQLKSNEL ERGH
