BH133_ARATH
ID BH133_ARATH Reviewed; 362 AA.
AC Q7XHI5; Q56XZ8; Q9SL72;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transcription factor bHLH133;
DE AltName: Full=Basic helix-loop-helix protein 133;
DE Short=AtbHLH133;
DE Short=bHLH 133;
DE AltName: Full=bHLH transcription factor bHLH133;
GN Name=BHLH133; OrderedLocusNames=At2g20100; ORFNames=T2G17.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q7XHI5; Q93Y00: BHLH7; NbExp=3; IntAct=EBI-15195839, EBI-4442198;
CC Q7XHI5; F4I171: MED15A; NbExp=3; IntAct=EBI-15195839, EBI-21254477;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7XHI5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7XHI5-2; Sequence=VSP_036106;
CC -!- SIMILARITY: Belongs to the bHLH protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD24388.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ577588; CAE12175.1; -; mRNA.
DR EMBL; AC006081; AAD24388.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06964.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06965.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62008.1; -; Genomic_DNA.
DR EMBL; AK221525; BAD94824.1; -; mRNA.
DR PIR; H84584; H84584.
DR RefSeq; NP_001077923.1; NM_001084454.2. [Q7XHI5-2]
DR RefSeq; NP_001324191.1; NM_001335660.1. [Q7XHI5-2]
DR RefSeq; NP_179600.2; NM_127568.5. [Q7XHI5-1]
DR AlphaFoldDB; Q7XHI5; -.
DR BioGRID; 1883; 4.
DR IntAct; Q7XHI5; 5.
DR STRING; 3702.AT2G20100.1; -.
DR PaxDb; Q7XHI5; -.
DR PRIDE; Q7XHI5; -.
DR ProteomicsDB; 240668; -. [Q7XHI5-1]
DR EnsemblPlants; AT2G20100.1; AT2G20100.1; AT2G20100. [Q7XHI5-1]
DR EnsemblPlants; AT2G20100.2; AT2G20100.2; AT2G20100. [Q7XHI5-2]
DR EnsemblPlants; AT2G20100.4; AT2G20100.4; AT2G20100. [Q7XHI5-2]
DR GeneID; 816529; -.
DR Gramene; AT2G20100.1; AT2G20100.1; AT2G20100. [Q7XHI5-1]
DR Gramene; AT2G20100.2; AT2G20100.2; AT2G20100. [Q7XHI5-2]
DR Gramene; AT2G20100.4; AT2G20100.4; AT2G20100. [Q7XHI5-2]
DR KEGG; ath:AT2G20100; -.
DR Araport; AT2G20100; -.
DR TAIR; locus:2061609; AT2G20100.
DR eggNOG; ENOG502QUMC; Eukaryota.
DR HOGENOM; CLU_041735_3_0_1; -.
DR InParanoid; Q7XHI5; -.
DR OMA; RIMASPN; -.
DR PhylomeDB; Q7XHI5; -.
DR PRO; PR:Q7XHI5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q7XHI5; baseline and differential.
DR Genevisible; Q7XHI5; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11393; bHLH_AtbHLH_like; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045239; bHLH95_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..362
FT /note="Transcription factor bHLH133"
FT /id="PRO_0000358816"
FT DOMAIN 209..258
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT VAR_SEQ 298..362
FT /note="LVNEYCMKRGVSLSSTDNQKSNPNEEPMKDLRSRGLCLVPISCTLQVGSDNG
FT ADYWAPAFGTTLQ -> VRTYIFLLSSFIYFTFYWIN (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_036106"
SQ SEQUENCE 362 AA; 40060 MW; D9A2389CD79E760F CRC64;
MNRGVLESSP VQHLTAAGNP NWWNNVSRGL RPPTPLMSHE PPSTTAFIPS LLPNFFSSPT
SSSSSSPSFP PPNSNPNFSS WLEMSDLPLD QPWSLSQLLL GGLMMGEEEK MEMMNHHHHQ
NQHQSYQAKR IQNWEEQVLR HQASMKQESS NNNSYGIMSS PNSPPNKSCA TIINTNEDNN
NNIHSGLNLS ECNSSEMIGS SFANKKPKLQ VPSSQSTLKV RKEKLGGRIA SLHQLVSPFG
KTDTASVLSE AIGYIRFLHS QIEALSLPYF GTPSRNNMMH QHAQRNMNGI FPEDPGQLVN
EYCMKRGVSL SSTDNQKSNP NEEPMKDLRS RGLCLVPISC TLQVGSDNGA DYWAPAFGTT
LQ
