ID   SIP5_YEAS7              Reviewed;         489 AA.
AC   A6ZMK0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Protein SIP5;
DE   AltName: Full=SNF1-interacting protein 5;
GN   Name=SIP5; ORFNames=SCY_4316;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: May negatively regulate the SNF1 kinase by promoting the
CC       interaction of the REG1/GLC7 phosphatase complex with the kinase.
CC       Deletion of SIP5 promotes resistance to artimisin, which is probably an
CC       indirect effect of an action on the electron transport chain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SNF1 and REG1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIP5 family. {ECO:0000305}.
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DR   EMBL; AAFW02000021; EDN64074.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZMK0; -.
DR   PRIDE; A6ZMK0; -.
DR   EnsemblFungi; EDN64074; EDN64074; SCY_4316.
DR   HOGENOM; CLU_009068_2_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039301; Sip5/DA2.
DR   PANTHER; PTHR31315; PTHR31315; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein.
FT   CHAIN           1..489
FT                   /note="Protein SIP5"
FT                   /id="PRO_0000333446"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          419..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        458..482
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         13
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40210"
FT   MOD_RES         183
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P40210"
FT   MOD_RES         433
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P40210"
FT   MOD_RES         436
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40210"
FT   MOD_RES         438
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P40210"
SQ   SEQUENCE   489 AA;  55814 MW;  BCF7C4D78A4B1854 CRC64;
     MGNVPGKIDQ EDSFNDVRPD SSYNTTSSNS VIKQYDEEAS SRVRTRRTTS LVNNILNGNN
     ARTKTGSHLS STSRRKTSRE KELAKEAHAK QLVVRCSETV DGGFLAPFGC YSFEKLDYDA
     TVVKNLIIKR KLAPFYTPLQ DFDESWTRDE LIKIVDGLPL HDTFDENLEE FEDVPIGNLR
     KSTFNELIDK SLSKKEQRRM HAKIFRARLY KKRILWQENE NETFLERKLE MKRIGSKSSN
     VEDNTSSQPR KNYHLPSDDL KYTLYKNGSE CPICFLYFPG PFNYSKCCQQ PICTECFVQI
     KRADPHFPHD EVDPTEPQTN DSEKDPNLLT SEPANCPYCA TASFSITYQP PTNRETGIGG
     MPADSYVYKD AAISRADGGQ PNIPAITSDT IRPDWEIKLN KERARLMRRS ANATAIHISN
     RLIDPSHSTR RNTSHSITPI HDESTSASRS PEPTINELED QMVREAIRLS LEDQDNRKKS
     KNRNTSLRP