ID   SIPD_SALTI              Reviewed;         340 AA.
AC   Q56136; Q7C7N3; Q8Z493;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Cell invasion protein SipD;
DE   AltName: Full=Salmonella invasion protein D;
GN   Name=sipD; Synonyms=sspD; OrderedLocusNames=STY3006, t2785;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=8801431; DOI=10.1111/j.1365-2958.1995.mmi_17040781.x;
RA   Hermant D., Menard R., Arricau N., Parsot C., Popoff M.Y.;
RT   "Functional conservation of the Salmonella and Shigella effectors of entry
RT   into epithelial cells.";
RL   Mol. Microbiol. 17:781-789(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Required for translocation of effector proteins via the type
CC       III secretion system SPI-1, which is essential for an efficient
CC       bacterial internalization. Probably acts by modulating the secretion of
CC       SipA, SipB, and SipC (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the
CC       type III secretion system 1 (SPI-1 TTSS). {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal domain is an intra-molecular chaperone that
CC       prevents premature oligomerization of the residues on the coiled-coil
CC       region that are involved in interactions with the needle and/or itself.
CC       The residues in the C-terminal domain probably form oligomeric
CC       structures at the tip of the needle that are responsible for the
CC       regulation of secretion of other effectors (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the invasin protein D family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA57990.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X82670; CAA57990.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL513382; CAD05990.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70346.1; -; Genomic_DNA.
DR   PIR; S70218; S70218.
DR   RefSeq; NP_457277.1; NC_003198.1.
DR   RefSeq; WP_000932243.1; NZ_WSUR01000005.1.
DR   AlphaFoldDB; Q56136; -.
DR   SMR; Q56136; -.
DR   STRING; 220341.16503961; -.
DR   EnsemblBacteria; AAO70346; AAO70346; t2785.
DR   KEGG; stt:t2785; -.
DR   KEGG; sty:STY3006; -.
DR   PATRIC; fig|220341.7.peg.3060; -.
DR   eggNOG; ENOG5032RHE; Bacteria.
DR   HOGENOM; CLU_069613_0_0_6; -.
DR   OMA; NYLGVYE; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1710.10; -; 1.
DR   InterPro; IPR036708; BipD-like_sf.
DR   InterPro; IPR009483; IpaD.
DR   Pfam; PF06511; T3SS_TC; 1.
DR   SUPFAM; SSF140693; SSF140693; 1.
DR   TIGRFAMs; TIGR02553; SipD_IpaD_SspD; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Secreted; Virulence.
FT   CHAIN           1..340
FT                   /note="Cell invasion protein SipD"
FT                   /id="PRO_0000219864"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          291..319
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   340 AA;  36549 MW;  425378F6CC254D3C CRC64;
     MLNIQNYSAS PHPGIVAERP QTPSASEHAE IAVVPSTTEH RGTDIISLSQ AATKIQQAQQ
     TLQSTPPISE ENNDERTLAR QQLTSSLNAL AKSGVSLSAE QNENLRSTFS APTSALFSAS
     PMAQPRTTIS DAEIWDMVSQ NISAIGDSYL GVYENVVAVY TDFYQAFSDI LSKMGGWLSP
     GKDGNTIKLN VDSLKSEISS LINKYTQINK NTILFPSQTG SGMTTATKAE AEQWIKELNL
     PDSCLKASGS GYVVLVDTGP LSKMVSDLNG IGSGSALELD NAKYQAWQSG FKAQEENLKT
     TLQTLTQKYS NANSLYDNLV KVLSSTISSS LETAKSFLQG