BH140_ARATH
ID BH140_ARATH Reviewed; 912 AA.
AC Q9M041;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Transcription factor bHLH140;
DE AltName: Full=Basic helix-loop-helix protein 140;
DE Short=AtbHLH140;
DE Short=bHLH 140;
DE AltName: Full=Transcription factor EN 122;
DE AltName: Full=bHLH transcription factor bHLH140;
GN Name=BHLH140; Synonyms=EN122; OrderedLocusNames=At5g01310;
GN ORFNames=T10O8.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; AL161746; CAB81914.1; -; Genomic_DNA.
DR EMBL; CP002688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; T48153; T48153.
DR AlphaFoldDB; Q9M041; -.
DR SMR; Q9M041; -.
DR STRING; 3702.AT5G01310.1; -.
DR iPTMnet; Q9M041; -.
DR PaxDb; Q9M041; -.
DR PRIDE; Q9M041; -.
DR EnsemblPlants; AT5G01305.1; AT5G01305.1; AT5G01305.
DR EnsemblPlants; AT5G01310.1; AT5G01310.1; AT5G01310.
DR Gramene; AT5G01305.1; AT5G01305.1; AT5G01305.
DR Gramene; AT5G01310.1; AT5G01310.1; AT5G01310.
DR Araport; AT5G01310; -.
DR TAIR; locus:2179122; AT5G01310.
DR eggNOG; KOG0562; Eukaryota.
DR eggNOG; KOG2134; Eukaryota.
DR HOGENOM; CLU_015173_0_0_1; -.
DR InParanoid; Q9M041; -.
DR PhylomeDB; Q9M041; -.
DR BioCyc; ARA:AT5G01310-MON; -.
DR PRO; PR:Q9M041; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9M041; baseline and differential.
DR Genevisible; Q9M041; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0047627; F:adenylylsulfatase activity; IDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0033699; F:DNA 5'-adenosine monophosphate hydrolase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:1990165; F:single-strand break-containing DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR GO; GO:0009150; P:purine ribonucleotide metabolic process; IDA:TAIR.
DR GO; GO:0000012; P:single strand break repair; IBA:GO_Central.
DR GO; GO:0006790; P:sulfur compound metabolic process; IDA:TAIR.
DR Gene3D; 3.30.428.10; -; 1.
DR Gene3D; 3.40.220.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR026963; Aprataxin-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR019808; Histidine_triad_CS.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032566; Znf-C2HE.
DR PANTHER; PTHR12486:SF4; PTHR12486:SF4; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01661; Macro; 1.
DR Pfam; PF16278; zf-C2HE; 1.
DR SMART; SM00506; A1pp; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF52949; SSF52949; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS00892; HIT_1; 1.
DR PROSITE; PS51084; HIT_2; 1.
DR PROSITE; PS51154; MACRO; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; DNA-binding; Metal-binding;
KW Nucleotide-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..912
FT /note="Transcription factor bHLH140"
FT /id="PRO_0000358820"
FT DOMAIN 43..92
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 511..690
FT /note="Macro"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00490"
FT DOMAIN 720..829
FT /note="HIT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00464"
FT ZN_FING 870..893
FT /note="C2H2-type"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 234..241
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 912 AA; 101388 MW; A2F400ED42A09457 CRC64;
MDDFNLRSEN PNSSSTTSSS SSSFHRHKSE TGNTKRSRST STLSTDPQSV AARDRRHRIS
DRFKILQSMV PGGAKMDTVS MLDEAISYVK FLKAQIWYHQ NMLLFINDHE TTSSCTYSPG
AGEFGPKLFG YDDDYAPIMD TYSQGVPLTV ADSKYTPWFG SVDDEQEHVT YFKYRRATRH
ALRGHCNCII GETEEFADQR EKMEVQIEES GKNQTSPESI EADKAKQIVV LLIGPPGSGK
STFCDTAMRS SHRPWSRICQ DIVNNGKAGT KAQCLKMATD SLREGKSVFI DRCNLDREQR
SEFIKLGGPE FEVHAVVLEL PAQVCISRSV KRTGHEGNLQ GGRAAAVVNK MLQSKELPKV
NEGFSRIMFC YSDADVDNAV NMYNKLGPMD TLPSGCFGEK KLDTKSQPGI MKFFKKVSAL
PASSSNEATN TTRKADEMTA NVRVSPVKLG SADIVPTLAF PSISTADFQF DLEKASDIIV
EKAEEFLSKL GTARLVLVDL SRGSKILSLV KAKASQKNID SAKFFTFVGD ITKLRSEGGL
HCNVIANATN WRLKPGGGGV NAAIFKAAGP DLETATRVRA NTLLPGKAVV VPLPSTCPLH
NAEGITHVIH VLGPNMNPNR PDNLNNDYTK GCKTLREAYT SLFEGFLSVV QDQSKLPKRS
SQTAVSDSGE DIKEDSERNK KYKGSQDKAV TNNLESESLE DTRGSGKKMS KGWNTWALAL
HSIAMHPERH ENVVLEYLDN IVVINDQYPK ARKHVLVLAR QESLDGLEDV RKENLQLLQE
MHNVGLKWVD RFQNEDASLI FRLGYHSVPS MRQLHLHVIS QDFNSDSLKN KKHWNSFTTS
FFRDSVDVLE EVNSQGKANV ASEDLLKGEL RCNRCRSAHP NIPKLKSHVR SCHSQFPDHL
LQNNRLVARA ET
