BH144_ARATH
ID BH144_ARATH Reviewed; 251 AA.
AC Q9ASX9; Q681I6; Q9FXG5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transcription factor bHLH144;
DE AltName: Full=Basic helix-loop-helix protein 144;
DE Short=AtbHLH144;
DE Short=bHLH 144;
DE AltName: Full=Transcription factor EN 130;
DE AltName: Full=bHLH transcription factor bHLH144;
GN Name=BHLH144; Synonyms=EN130; OrderedLocusNames=At1g29950;
GN ORFNames=F1N18.24, T1P2.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [7]
RP INTERACTION WITH LHW.
RX PubMed=17626058; DOI=10.1242/dev.006296;
RA Ohashi-Ito K., Bergmann D.C.;
RT "Regulation of the Arabidopsis root vascular initial population by LONESOME
RT HIGHWAY.";
RL Development 134:2959-2968(2007).
CC -!- SUBUNIT: Homodimer (Probable). Interacts with LHW.
CC {ECO:0000269|PubMed:17626058, ECO:0000305}.
CC -!- INTERACTION:
CC Q9ASX9; Q9FGB0: BHLH145; NbExp=3; IntAct=EBI-15195383, EBI-4477059;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG10601.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG52051.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC008030; AAG10601.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC022455; AAG52051.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31153.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31154.1; -; Genomic_DNA.
DR EMBL; AF361607; AAK32775.1; -; mRNA.
DR EMBL; AY074843; AAL69541.1; -; mRNA.
DR EMBL; AK175631; BAD43394.1; -; mRNA.
DR EMBL; AK230374; BAF02173.1; -; mRNA.
DR PIR; C86423; C86423.
DR RefSeq; NP_564342.1; NM_102735.3.
DR RefSeq; NP_973937.1; NM_202208.1.
DR AlphaFoldDB; Q9ASX9; -.
DR SMR; Q9ASX9; -.
DR BioGRID; 926799; 5.
DR IntAct; Q9ASX9; 5.
DR STRING; 3702.AT1G29950.2; -.
DR PaxDb; Q9ASX9; -.
DR PRIDE; Q9ASX9; -.
DR EnsemblPlants; AT1G29950.1; AT1G29950.1; AT1G29950.
DR EnsemblPlants; AT1G29950.2; AT1G29950.2; AT1G29950.
DR GeneID; 6240759; -.
DR Gramene; AT1G29950.1; AT1G29950.1; AT1G29950.
DR Gramene; AT1G29950.2; AT1G29950.2; AT1G29950.
DR KEGG; ath:AT1G29950; -.
DR Araport; AT1G29950; -.
DR TAIR; locus:2198253; AT1G29950.
DR eggNOG; ENOG502R4DP; Eukaryota.
DR HOGENOM; CLU_093993_0_0_1; -.
DR InParanoid; Q9ASX9; -.
DR OMA; QIMYHPA; -.
DR OrthoDB; 1211331at2759; -.
DR PhylomeDB; Q9ASX9; -.
DR PRO; PR:Q9ASX9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ASX9; baseline and differential.
DR Genevisible; Q9ASX9; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037546; SAC51-like.
DR PANTHER; PTHR36066; PTHR36066; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..251
FT /note="Transcription factor bHLH144"
FT /id="PRO_0000358822"
FT DOMAIN 186..235
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 251 AA; 27822 MW; 33A81B80C3ECF7D3 CRC64;
MQNNQFPHFS DEVGDRNMHN PYASGSSYDA LFPPCAKLPY HGVELQPSAV CPKNFVIFDQ
TYDRSQVMYH PELTHKLMNT PSLNNLASTF QNEYVGGSYG NYGNYEQEVS SSYQEDPNEI
DALLSADEDY EENDDNEGEE DGGDSEEVST ARTSSRDYGN TTAESCCSSY GYNNNNNNNS
RKQSLSGSAS SSNNDGKGRK KMKKMMGVLR RIVPGGEQMN TACVLDEAVQ YLKSLKIEAQ
KLGVGHFSNQ S
