ID   SIRB1_SALTY             Reviewed;         269 AA.
AC   P0A2L9; Q9XCQ1;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein SirB1;
GN   Name=sirB1; Synonyms=orf1 {ECO:0000303|PubMed:10322010};
GN   OrderedLocusNames=STM1773;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PUTATIVE FUNCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=10322010; DOI=10.1128/jb.181.10.3096-3104.1999;
RA   Rakeman J.L., Bonifield H.R., Miller S.I.;
RT   "A HilA-independent pathway to Salmonella typhimurium invasion gene
RT   transcription.";
RL   J. Bacteriol. 181:3096-3104(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Required for maximal expression of sirC, not required to
CC       invade host cells. {ECO:0000269|PubMed:10322010}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for the ability to invade cultured
CC       HeLa cells (the invasive phenotype). {ECO:0000269|PubMed:10322010}.
CC   -!- SIMILARITY: Belongs to the UPF0162 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF134855; AAD32200.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20688.1; -; Genomic_DNA.
DR   RefSeq; NP_460729.1; NC_003197.2.
DR   RefSeq; WP_001257065.1; NC_003197.2.
DR   AlphaFoldDB; P0A2L9; -.
DR   SMR; P0A2L9; -.
DR   STRING; 99287.STM1773; -.
DR   PaxDb; P0A2L9; -.
DR   EnsemblBacteria; AAL20688; AAL20688; STM1773.
DR   GeneID; 1253292; -.
DR   KEGG; stm:STM1773; -.
DR   PATRIC; fig|99287.12.peg.1868; -.
DR   HOGENOM; CLU_063810_0_0_6; -.
DR   OMA; LWIAAEH; -.
DR   PhylomeDB; P0A2L9; -.
DR   BioCyc; SENT99287:STM1773-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   InterPro; IPR032698; SirB1_N.
DR   Pfam; PF13369; Transglut_core2; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..269
FT                   /note="Protein SirB1"
FT                   /id="PRO_0000202380"
FT   CONFLICT        174
FT                   /note="A -> T (in Ref. 1; AAD32200)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  30924 MW;  3F867C6511A7AFA3 CRC64;
     MRSLADFEFN NAPLCDGMIL ASEMIRLDFP TQFVYDELER LVSLAQEEIS QLLSQDEQLE
     KLLALFYGEW GFTDSRGVYR LSDALWLDKV LKKRQGSAVS LGAILLWIAN RLDLPLVPVI
     FPTQLILRIE SLEGEMWLIN PFNGETLDEH TLEVWLKGNI SPVAELFNED LDEADNAEVI
     RKLLDTLKSS LMEERQMELA LRVSEALLQF NPEDPYEIRD RGLIYAQLEC EHVALTDLSY
     FVEQCPEDPI SEMIRAQINT IAHKQIVLH