SIRB2_HUMAN
ID SIRB2_HUMAN Reviewed; 342 AA.
AC Q5JXA9; B4DLM9; E9PCW6; Q6TCH9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Signal-regulatory protein beta-2;
DE Short=SIRP-beta-2;
DE AltName: Full=Protein tyrosine phosphatase non-receptor type substrate 1-like 3;
DE AltName: Full=Protein tyrosine phosphatase non-receptor type substrate protein;
DE Flags: Precursor;
GN Name=SIRPB2; Synonyms=PTPN1L, PTPNS1L3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ALA-215.
RA Li H., Zhong G., Zheng G., Ke R., Zhou G., Shen C., Lin L., Yang S.;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT ALA-215.
RC TISSUE=Umbilical cord blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5JXA9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JXA9-2; Sequence=VSP_034065, VSP_034066;
CC Name=3;
CC IsoId=Q5JXA9-3; Sequence=VSP_034065;
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DR EMBL; AY424277; AAR04783.1; -; mRNA.
DR EMBL; AK297072; BAG59591.1; -; mRNA.
DR EMBL; AL109658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42849.1; -. [Q5JXA9-1]
DR CCDS; CCDS46570.1; -. [Q5JXA9-3]
DR RefSeq; NP_001116434.1; NM_001122962.1. [Q5JXA9-1]
DR RefSeq; NP_001128308.1; NM_001134836.1. [Q5JXA9-3]
DR AlphaFoldDB; Q5JXA9; -.
DR SMR; Q5JXA9; -.
DR STRING; 9606.ENSP00000352849; -.
DR GlyGen; Q5JXA9; 3 sites.
DR iPTMnet; Q5JXA9; -.
DR PhosphoSitePlus; Q5JXA9; -.
DR BioMuta; SIRPB2; -.
DR DMDM; 74762205; -.
DR MassIVE; Q5JXA9; -.
DR PaxDb; Q5JXA9; -.
DR PeptideAtlas; Q5JXA9; -.
DR PRIDE; Q5JXA9; -.
DR ProteomicsDB; 63437; -. [Q5JXA9-1]
DR Antibodypedia; 62736; 116 antibodies from 15 providers.
DR DNASU; 284759; -.
DR Ensembl; ENST00000359801.8; ENSP00000352849.3; ENSG00000196209.13. [Q5JXA9-1]
DR Ensembl; ENST00000444444.2; ENSP00000402438.1; ENSG00000196209.13. [Q5JXA9-3]
DR GeneID; 284759; -.
DR KEGG; hsa:284759; -.
DR MANE-Select; ENST00000359801.8; ENSP00000352849.3; NM_001122962.2; NP_001116434.1.
DR UCSC; uc002wfg.3; human. [Q5JXA9-1]
DR CTD; 284759; -.
DR DisGeNET; 284759; -.
DR GeneCards; SIRPB2; -.
DR HGNC; HGNC:16247; SIRPB2.
DR HPA; ENSG00000196209; Tissue enhanced (lymphoid).
DR neXtProt; NX_Q5JXA9; -.
DR OpenTargets; ENSG00000196209; -.
DR PharmGKB; PA164742382; -.
DR VEuPathDB; HostDB:ENSG00000196209; -.
DR eggNOG; ENOG502SR6W; Eukaryota.
DR GeneTree; ENSGT00960000186656; -.
DR HOGENOM; CLU_073754_0_0_1; -.
DR InParanoid; Q5JXA9; -.
DR OMA; PCSWLLA; -.
DR OrthoDB; 740991at2759; -.
DR PhylomeDB; Q5JXA9; -.
DR TreeFam; TF341862; -.
DR PathwayCommons; Q5JXA9; -.
DR BioGRID-ORCS; 284759; 11 hits in 1067 CRISPR screens.
DR ChiTaRS; SIRPB2; human.
DR GenomeRNAi; 284759; -.
DR Pharos; Q5JXA9; Tdark.
DR PRO; PR:Q5JXA9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q5JXA9; protein.
DR Bgee; ENSG00000196209; Expressed in monocyte and 100 other tissues.
DR ExpressionAtlas; Q5JXA9; baseline and differential.
DR Genevisible; Q5JXA9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..342
FT /note="Signal-regulatory protein beta-2"
FT /id="PRO_0000338629"
FT TOPO_DOM 33..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 33..143
FT /note="Ig-like V-type 1"
FT DOMAIN 157..258
FT /note="Ig-like V-type 2"
FT REGION 317..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 60..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 180..242
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 53..150
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_034065"
FT VAR_SEQ 290..342
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034066"
FT VARIANT 153
FT /note="G -> E (in dbSNP:rs6033876)"
FT /id="VAR_043814"
FT VARIANT 215
FT /note="E -> A (in dbSNP:rs6042507)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.1"
FT /id="VAR_043815"
FT VARIANT 304
FT /note="L -> F (in dbSNP:rs8119290)"
FT /id="VAR_043816"
FT CONFLICT 289
FT /note="L -> Q (in Ref. 1; AAR04783)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 36968 MW; 5D0B35E6FD8E29B9 CRC64;
MCSTMSAPTC LAHLPPCFLL LALVLVPSDA SGQSSRNDWQ VLQPEGPMLV AEGETLLLRC
MVVGSCTDGM IKWVKVSTQD QQEIYNFKRG SFPGVMPMIQ RTSEPLNCDY SIYIHNVTRE
HTGTYHCVRF DGLSEHSEMK SDEGTSVLVK GAGDPEPDLW IIQPQELVLG TTGDTVFLNC
TVLGDGPPGP IRWFQGAGLS REAIYNFGGI SHPKETAVQA SNNDFSILLQ NVSSEDAGTY
YCVKFQRKPN RQYLSGQGTS LKVKAKSTSS KEAEFTSEPA TEMSPTGLLV VFAPVVLGLK
AITLAALLLA LATSRRSPGQ EDVKTTGPAG AMNTLAWSKG QE
