SIRB2_SALTI
ID SIRB2_SALTI Reviewed; 129 AA.
AC P0A238; Q9XCQ2;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Protein SirB2;
GN Name=sirB2; OrderedLocusNames=STY1899, t1102;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Required for maximal expression of sirC, not required to
CC invade host cells. {ECO:0000250|UniProtKB:P0A237}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:Q46755}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SirB2 family. {ECO:0000305}.
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DR EMBL; AL513382; CAD02129.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68765.1; -; Genomic_DNA.
DR RefSeq; NP_456284.1; NC_003198.1.
DR RefSeq; WP_000150667.1; NZ_WSUR01000004.1.
DR AlphaFoldDB; P0A238; -.
DR SMR; P0A238; -.
DR STRING; 220341.16502963; -.
DR EnsemblBacteria; AAO68765; AAO68765; t1102.
DR KEGG; stt:t1102; -.
DR KEGG; sty:STY1899; -.
DR PATRIC; fig|220341.7.peg.1913; -.
DR eggNOG; COG3094; Bacteria.
DR HOGENOM; CLU_123860_3_0_6; -.
DR OMA; WVVYAAK; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007360; SirB.
DR PANTHER; PTHR39594; PTHR39594; 1.
DR Pfam; PF04247; SirB; 1.
DR PIRSF; PIRSF005610; SirB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..129
FT /note="Protein SirB2"
FT /id="PRO_0000097771"
FT TOPO_DOM 1..2
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..71
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..129
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 129 AA; 14467 MW; 357A5277DD59371D CRC64;
MTIAMLLTLH LICVALSVSL FVARYWWRYC GHALAAARWT RIVPPVIDTL LLLSGIGLIV
KTHILPFTES GSWLTEKLFG VIIYIVLGFI ALDYRQARSQ QARFIAFPLA LVVLYIIIKL
ATTKIPLLG
