SIRB2_SALTY
ID SIRB2_SALTY Reviewed; 129 AA.
AC P0A237; Q9XCQ2;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Protein SirB2;
GN Name=sirB2; Synonyms=orf2 {ECO:0000303|PubMed:10322010};
GN OrderedLocusNames=STM1774;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PUTATIVE FUNCTION, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=10322010; DOI=10.1128/jb.181.10.3096-3104.1999;
RA Rakeman J.L., Bonifield H.R., Miller S.I.;
RT "A HilA-independent pathway to Salmonella typhimurium invasion gene
RT transcription.";
RL J. Bacteriol. 181:3096-3104(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Required for maximal expression of sirC, not required to
CC invade host cells. {ECO:0000269|PubMed:10322010}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:Q46755}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Not essential for the ability to invade cultured
CC HeLa cells (the invasive phenotype). {ECO:0000269|PubMed:10322010}.
CC -!- SIMILARITY: Belongs to the SirB2 family. {ECO:0000305}.
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DR EMBL; AF134855; AAD32201.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20689.1; -; Genomic_DNA.
DR RefSeq; NP_460730.1; NC_003197.2.
DR RefSeq; WP_000150667.1; NC_003197.2.
DR AlphaFoldDB; P0A237; -.
DR SMR; P0A237; -.
DR STRING; 99287.STM1774; -.
DR PaxDb; P0A237; -.
DR EnsemblBacteria; AAL20689; AAL20689; STM1774.
DR GeneID; 1253293; -.
DR KEGG; stm:STM1774; -.
DR PATRIC; fig|99287.12.peg.1869; -.
DR HOGENOM; CLU_123860_3_0_6; -.
DR OMA; WVVYAAK; -.
DR PhylomeDB; P0A237; -.
DR BioCyc; SENT99287:STM1774-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR007360; SirB.
DR PANTHER; PTHR39594; PTHR39594; 1.
DR Pfam; PF04247; SirB; 1.
DR PIRSF; PIRSF005610; SirB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..129
FT /note="Protein SirB2"
FT /id="PRO_0000097772"
FT TOPO_DOM 1..2
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..71
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..129
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 129 AA; 14467 MW; 357A5277DD59371D CRC64;
MTIAMLLTLH LICVALSVSL FVARYWWRYC GHALAAARWT RIVPPVIDTL LLLSGIGLIV
KTHILPFTES GSWLTEKLFG VIIYIVLGFI ALDYRQARSQ QARFIAFPLA LVVLYIIIKL
ATTKIPLLG
