BH149_ARATH
ID BH149_ARATH Reviewed; 207 AA.
AC O80482;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transcription factor bHLH149;
DE AltName: Full=ATBS1 interacting factor 4;
DE AltName: Full=Basic helix-loop-helix protein 149;
DE Short=AtbHLH149;
DE Short=bHLH 149;
DE AltName: Full=Transcription factor EN 144;
DE AltName: Full=bHLH transcription factor bHLH149;
GN Name=BHLH149; Synonyms=AIF4, EN144; OrderedLocusNames=At1g09250;
GN ORFNames=T12M4.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [7]
RP FUNCTION, AND INTERACTION WITH PRE3.
RC STRAIN=cv. Columbia;
RX PubMed=20023194; DOI=10.1105/tpc.109.072504;
RA Wang H., Zhu Y., Fujioka S., Asami T., Li J., Li J.;
RT "Regulation of Arabidopsis brassinosteroid signaling by atypical basic
RT helix-loop-helix proteins.";
RL Plant Cell 21:3781-3791(2009).
CC -!- FUNCTION: Atypical bHLH transcription factor probably unable to bind
CC DNA. Negatively regulates brassinosteroid signaling.
CC {ECO:0000269|PubMed:20023194}.
CC -!- SUBUNIT: Homodimer (Probable). Interacts with PRE3.
CC {ECO:0000269|PubMed:20023194, ECO:0000305}.
CC -!- INTERACTION:
CC O80482; Q9LV17: BHLH79; NbExp=4; IntAct=EBI-15193669, EBI-15191993;
CC O80482; F4JCN9: PRE4; NbExp=3; IntAct=EBI-15193669, EBI-15192623;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; AC003114; AAC24081.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28419.1; -; Genomic_DNA.
DR EMBL; BT003052; AAO23617.1; -; mRNA.
DR EMBL; AK227577; BAE99570.1; -; mRNA.
DR PIR; D86225; D86225.
DR RefSeq; NP_563839.1; NM_100795.4.
DR AlphaFoldDB; O80482; -.
DR SMR; O80482; -.
DR BioGRID; 22687; 11.
DR IntAct; O80482; 10.
DR STRING; 3702.AT1G09250.1; -.
DR PaxDb; O80482; -.
DR PRIDE; O80482; -.
DR EnsemblPlants; AT1G09250.1; AT1G09250.1; AT1G09250.
DR GeneID; 837446; -.
DR Gramene; AT1G09250.1; AT1G09250.1; AT1G09250.
DR KEGG; ath:AT1G09250; -.
DR Araport; AT1G09250; -.
DR TAIR; locus:2195291; AT1G09250.
DR eggNOG; ENOG502RY2C; Eukaryota.
DR HOGENOM; CLU_090794_0_1_1; -.
DR InParanoid; O80482; -.
DR OMA; PVNAGRA; -.
DR OrthoDB; 1633126at2759; -.
DR PhylomeDB; O80482; -.
DR PRO; PR:O80482; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O80482; baseline and differential.
DR Genevisible; O80482; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:UniProt.
DR CDD; cd11444; bHLH_AtIBH1_like; 1.
DR InterPro; IPR044549; bHLH_AtIBH1-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR044660; IBH1-like.
DR PANTHER; PTHR33124; PTHR33124; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..207
FT /note="Transcription factor bHLH149"
FT /id="PRO_0000358826"
FT DOMAIN 132..181
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 23153 MW; 5F59927B6679473E CRC64;
MVESLFPSIE NTGESSRRKK PRISETAEAE IEARRVNEES LKRWKTNRVQ QIYACKLVEA
LRRVRQRSST TSNNETDKLV SGAAREIRDT ADRVLAASAR GTTRWSRAIL ASRVRAKLKK
HRKAKKSTGN CKSRKGLTET NRIKLPAVER KLKILGRLVP GCRKVSVPNL LDEATDYIAA
LEMQVRAMEA LAELLTAAAP RTTLTGT
