SIRC_SALTI
ID SIRC_SALTI Reviewed; 295 AA.
AC Q8Z4A6;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Transcriptional regulator SirC;
GN Name=sirC; Synonyms=hilC, sprA; OrderedLocusNames=STY2988, t2769;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Positive regulator of the expression of the invasion-
CC associated type III secretion system encoded within SPI-1
CC (pathogenicity island 1). {ECO:0000250}.
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DR EMBL; AL513382; CAD05974.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70330.1; -; Genomic_DNA.
DR RefSeq; NP_457261.1; NC_003198.1.
DR RefSeq; WP_000243995.1; NZ_WSUR01000005.1.
DR AlphaFoldDB; Q8Z4A6; -.
DR SMR; Q8Z4A6; -.
DR STRING; 220341.16503945; -.
DR EnsemblBacteria; AAO70330; AAO70330; t2769.
DR KEGG; stt:t2769; -.
DR KEGG; sty:STY2988; -.
DR PATRIC; fig|220341.7.peg.3043; -.
DR eggNOG; COG2207; Bacteria.
DR HOGENOM; CLU_000445_81_4_6; -.
DR OMA; YSYYSLM; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR Pfam; PF12833; HTH_18; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..295
FT /note="Transcriptional regulator SirC"
FT /id="PRO_0000194581"
FT DOMAIN 195..292
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 212..233
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 259..282
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 295 AA; 33871 MW; 0F041D661A62A83A CRC64;
MVLPSMNKSV EAISNNHLQQ PNKFPLINGL ADVRDYYVAN CLLFKLNKGS LRIENEFGEF
IEQSALCLFL LEKDQTITLS MSEIEGHIDF SSLEVSYDLM QKFYKVFYST RNYNDRELSL
KTKPKYFFHA DLLPGMSDTF DSILHGVACP RVCSNVSIDD HDYSYFSLMY LISAFVRKPG
GFDFLERAIK ITTKEKVYNI IISDLTRKWS QAEVAGKLFM SVSSLKRKLA AEEVSFSKIY
LDARMNQAIK LLRMGAGNIS QVATMCGYDT PSYFIAIFKR HFKITPLSFM RTMNH
