SIRC_SALTS
ID SIRC_SALTS Reviewed; 295 AA.
AC E1WAB2; Q9R3W3; Q9XCQ0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Transcriptional regulator SirC;
GN Name=sirC; Synonyms=hilC, sprA; OrderedLocusNames=SL1344_2847;
OS Salmonella typhimurium (strain SL1344).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=216597;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SL1344;
RX PubMed=10411731; DOI=10.1046/j.1365-2958.1999.01458.x;
RA Eichelberg K., Hardt W.-D., Galan J.E.;
RT "Characterization of SprA, an AraC-like transcriptional regulator encoded
RT within the salmonella typhimurium pathogenicity island 1.";
RL Mol. Microbiol. 33:139-152(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SL1344;
RX PubMed=10320584; DOI=10.1046/j.1365-2958.1999.01381.x;
RA Schechter L.M., Damrauer S.M., Lee C.A.;
RT "Two AraC/XylS family members can independently counteract the effect of
RT repressing sequences upstream of the hilA promoter.";
RL Mol. Microbiol. 32:629-642(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SL1344;
RX PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT "The transcriptional landscape and small RNAs of Salmonella enterica
RT serovar Typhimurium.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
CC -!- FUNCTION: Positive regulator of the expression of the invasion-
CC associated type III secretion system encoded within SPI-1
CC (pathogenicity island 1). {ECO:0000250}.
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DR EMBL; AF148689; AAD37784.1; -; Genomic_DNA.
DR EMBL; AF124397; AAD21080.1; -; Genomic_DNA.
DR EMBL; FQ312003; CBW18945.1; -; Genomic_DNA.
DR RefSeq; WP_000243999.1; NZ_QASL01000017.1.
DR AlphaFoldDB; E1WAB2; -.
DR SMR; E1WAB2; -.
DR EnsemblBacteria; CBW18945; CBW18945; SL1344_2847.
DR KEGG; sey:SL1344_2847; -.
DR PATRIC; fig|216597.6.peg.3168; -.
DR HOGENOM; CLU_000445_81_4_6; -.
DR OMA; YSYYSLM; -.
DR BioCyc; SENT216597:SL1344_RS14845-MON; -.
DR Proteomes; UP000008962; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR Pfam; PF12833; HTH_18; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..295
FT /note="Transcriptional regulator SirC"
FT /id="PRO_0000405420"
FT DOMAIN 195..292
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 212..233
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 259..282
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 295 AA; 33883 MW; 388CC1EBD3033F76 CRC64;
MVLPSMNKSV EAISNNHLQQ PNKFPLINGL ADVRDYYVAN CLLFKLNKGS LRIENEFGEF
IERSAPCLFL LEKDQTITLS MSEIEGHIDF SSLEVSYDLM QKFYKVFYST RNYNDRELSL
KTKPKYFFHA DLLPGMSDTF DSILHGVACP RVCSNVSIDD HDYSYFSLMY LISAFVRKPG
GFDFLERAIK ITTKEKVYNI IISDLTRKWS QAEVAGKLFM SVSSLKRKLA AEEVSFSKIY
LDARMNQAIK LLRMGAGNIS QVATMCGYDT PSYFIAIFKR HFKITPLSFM RTMNH
