SIRC_SALTY
ID SIRC_SALTY Reviewed; 295 AA.
AC P0CL09; Q9R3W3; Q9XCQ0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Transcriptional regulator sirC;
GN Name=sirC; Synonyms=hilC, sprA; OrderedLocusNames=STM2867;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PUTATIVE FUNCTION.
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=10322010; DOI=10.1128/jb.181.10.3096-3104.1999;
RA Rakeman J.L., Bonifield H.R., Miller S.I.;
RT "A HilA-independent pathway to Salmonella typhimurium invasion gene
RT transcription.";
RL J. Bacteriol. 181:3096-3104(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Positive regulator of the expression of the invasion-
CC associated type III secretion system encoded within SPI-1
CC (pathogenicity island 1).
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DR EMBL; AF134856; AAD32202.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21747.1; -; Genomic_DNA.
DR RefSeq; NP_461788.1; NC_003197.2.
DR RefSeq; WP_000243999.1; NC_003197.2.
DR AlphaFoldDB; P0CL09; -.
DR SMR; P0CL09; -.
DR STRING; 99287.STM2867; -.
DR PaxDb; P0CL09; -.
DR DNASU; 1254390; -.
DR EnsemblBacteria; AAL21747; AAL21747; STM2867.
DR GeneID; 1254390; -.
DR KEGG; stm:STM2867; -.
DR PATRIC; fig|99287.12.peg.3023; -.
DR HOGENOM; CLU_000445_81_4_6; -.
DR OMA; YSYYSLM; -.
DR PhylomeDB; P0CL09; -.
DR BioCyc; SENT99287:STM2867-MON; -.
DR PHI-base; PHI:631; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR Pfam; PF12833; HTH_18; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 4: Predicted;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..295
FT /note="Transcriptional regulator sirC"
FT /id="PRO_0000194582"
FT DOMAIN 195..292
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 212..233
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 259..282
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT VARIANT 22
FT /note="N -> D (in strain: ATCC 14028 / SGSG 2980 / CDC
FT 6516-60 / NCTC 12023)"
FT VARIANT 271
FT /note="P -> L (in strain: ATCC 14028 / SGSG 2980 / CDC
FT 6516-60 / NCTC 12023)"
SQ SEQUENCE 295 AA; 33883 MW; 388CC1EBD3033F76 CRC64;
MVLPSMNKSV EAISNNHLQQ PNKFPLINGL ADVRDYYVAN CLLFKLNKGS LRIENEFGEF
IERSAPCLFL LEKDQTITLS MSEIEGHIDF SSLEVSYDLM QKFYKVFYST RNYNDRELSL
KTKPKYFFHA DLLPGMSDTF DSILHGVACP RVCSNVSIDD HDYSYFSLMY LISAFVRKPG
GFDFLERAIK ITTKEKVYNI IISDLTRKWS QAEVAGKLFM SVSSLKRKLA AEEVSFSKIY
LDARMNQAIK LLRMGAGNIS QVATMCGYDT PSYFIAIFKR HFKITPLSFM RTMNH
