BH151_ARATH
ID BH151_ARATH Reviewed; 102 AA.
AC O22901; C0SV93; Q8LDJ3;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transcription factor UPBEAT1;
DE AltName: Full=Basic helix-loop-helix protein 151;
DE Short=AtbHLH151;
DE Short=bHLH 151;
DE AltName: Full=Transcription factor EN 146;
DE AltName: Full=Transcription factor bHLH151;
DE AltName: Full=bHLH transcription factor bHLH151;
GN Name=UPB1; Synonyms=BHLH151, EN146; OrderedLocusNames=At2g47270;
GN ORFNames=T8I13.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND INDUCTION.
RX PubMed=21074051; DOI=10.1016/j.cell.2010.10.020;
RA Tsukagoshi H., Busch W., Benfey P.N.;
RT "Transcriptional regulation of ROS controls transition from proliferation
RT to differentiation in the root.";
RL Cell 143:606-616(2010).
CC -!- FUNCTION: Transcription factor that modulates the balance between
CC cellular proliferation and differentiation in root growth. Does not act
CC through cytokinin and auxin signaling, but by repressing peroxidase
CC expression in the elongation zone. {ECO:0000269|PubMed:21074051}.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981,
CC ECO:0000269|PubMed:21074051}.
CC -!- TISSUE SPECIFICITY: Expressed in the root vascular tissue and in root
CC hairs and lateral root caps. Detected at the protein level in all cell
CC files in the elongation zone. {ECO:0000269|PubMed:21074051}.
CC -!- INDUCTION: Up-regulated by reactive oxygen species.
CC {ECO:0000269|PubMed:21074051}.
CC -!- DISRUPTION PHENOTYPE: Enlargment of the meristem and longer root
CC length. {ECO:0000269|PubMed:21074051}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63189.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002337; AAB63827.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10822.1; -; Genomic_DNA.
DR EMBL; BT024807; ABD60690.1; -; mRNA.
DR EMBL; AY085979; AAM63189.1; ALT_INIT; mRNA.
DR EMBL; AB493596; BAH30434.1; -; mRNA.
DR PIR; B84913; B84913.
DR RefSeq; NP_566098.1; NM_130295.3.
DR AlphaFoldDB; O22901; -.
DR SMR; O22901; -.
DR BioGRID; 4675; 2.
DR IntAct; O22901; 2.
DR STRING; 3702.AT2G47270.1; -.
DR PaxDb; O22901; -.
DR PRIDE; O22901; -.
DR ProteomicsDB; 240684; -.
DR EnsemblPlants; AT2G47270.1; AT2G47270.1; AT2G47270.
DR GeneID; 819340; -.
DR Gramene; AT2G47270.1; AT2G47270.1; AT2G47270.
DR KEGG; ath:AT2G47270; -.
DR Araport; AT2G47270; -.
DR TAIR; locus:2065134; AT2G47270.
DR eggNOG; ENOG502S5A4; Eukaryota.
DR HOGENOM; CLU_161672_0_0_1; -.
DR InParanoid; O22901; -.
DR OMA; MLMKRIP; -.
DR OrthoDB; 1597101at2759; -.
DR PhylomeDB; O22901; -.
DR PRO; PR:O22901; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22901; baseline and differential.
DR Genevisible; O22901; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:2000280; P:regulation of root development; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR CDD; cd11444; bHLH_AtIBH1_like; 1.
DR InterPro; IPR044549; bHLH_AtIBH1-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR044660; IBH1-like.
DR PANTHER; PTHR33124; PTHR33124; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Differentiation; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..102
FT /note="Transcription factor UPBEAT1"
FT /id="PRO_0000358828"
FT DOMAIN 32..82
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT CONFLICT 87
FT /note="K -> R (in Ref. 4; AAM63189)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="N -> D (in Ref. 4; AAM63189)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 102 AA; 11879 MW; 77DE9C9303F420AD CRC64;
MGVTLEGQRK ESIWVLMRRQ RARRALVKKI MIRPRKSVEA SRRPCRAIHR RVKTLKELVP
NTKTSEGLDG LFRQTADYIL ALEMKVKVMQ TMVQVLTETN CV
