ID   SIRZ_LEPMC              Reviewed;         500 AA.
AC   Q6Q877;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=C6 finger domain transcription factor sirZ {ECO:0000303|PubMed:15387811};
DE   AltName: Full=Sirodesmin production protein Z {ECO:0000303|PubMed:15387811};
GN   Name=sirZ {ECO:0000303|PubMed:15387811};
OS   Leptosphaeria maculans (Blackleg fungus) (Phoma lingam).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Leptosphaeria; Leptosphaeria maculans species complex.
OX   NCBI_TaxID=5022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=15387811; DOI=10.1111/j.1365-2958.2004.04215.x;
RA   Gardiner D.M., Cozijnsen A.J., Wilson L.M., Pedras M.S., Howlett B.J.;
RT   "The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus
RT   Leptosphaeria maculans.";
RL   Mol. Microbiol. 53:1307-1318(2004).
RN   [2]
RP   INDUCTION.
RX   PubMed=20507539; DOI=10.1111/j.1364-3703.2007.00433.x;
RA   Elliott C.E., Gardiner D.M., Thomas G., Cozijnsen A., Van de Wouw A.,
RA   Howlett B.J.;
RT   "Production of the toxin sirodesmin PL by Leptosphaeria maculans during
RT   infection of Brassica napus.";
RL   Mol. Plant Pathol. 8:791-802(2007).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=18023597; DOI=10.1016/j.fgb.2007.10.005;
RA   Fox E.M., Gardiner D.M., Keller N.P., Howlett B.J.;
RT   "A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic
RT   gene cluster in Leptosphaeria maculans.";
RL   Fungal Genet. Biol. 45:671-682(2008).
CC   -!- FUNCTION: Transcription factor that regulates sirodesmin production and
CC       contributes to virulence (PubMed:15387811, PubMed:18023597). Probably
CC       binds to the consensus motif TCGGN(3)CCGA found in the promoters of
CC       sirT, sirP, sirO, sirN, sirP, sirB, sirR, sirJ and sirQ
CC       (PubMed:18023597). {ECO:0000269|PubMed:15387811,
CC       ECO:0000269|PubMed:18023597}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expressed during canola infection (PubMed:20507539).
CC       Expression is co-regulated with the other genes from the sirodesmin
CC       cluster and corresponds with sirodesmin production (PubMed:15387811).
CC       {ECO:0000269|PubMed:15387811, ECO:0000269|PubMed:20507539}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced production of sirodesmin PL and
CC       decreased transcription of sirodesmin PL biosynthetic genes
CC       (PubMed:18023597). {ECO:0000269|PubMed:18023597}.
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DR   EMBL; AY553235; AAS92551.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6Q877; -.
DR   SMR; Q6Q877; -.
DR   PRIDE; Q6Q877; -.
DR   OMA; STFIGCA; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..500
FT                   /note="C6 finger domain transcription factor sirZ"
FT                   /id="PRO_0000437713"
FT   DNA_BIND        28..54
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          79..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   500 AA;  54706 MW;  F58593335FB4EEF6 CRC64;
     MSPAPPPCGF AEAESTNTKS APKFRSACNA CHEVKLKCLG GQPCARCRNK QVECVYSHAA
     RIGKPKGSRN KKTLERLRQA KAMSRPEETQ GEETTSLTAV DASQAINCRA LSGSTRRDSS
     PLPPPHSDTD SAEGGAEEEL LDQEERDEAE KPPLVENPPN LNPLEQISPP REDFLDLLAH
     SSLLNNTQHD LQHPTADMVP DGLAGFPHAS TSAADDLSWM TSPTKSLLST TFPAIEDDLQ
     DLQDPFLCSS WRSACLPPSS SRSSFHFPRF NHFAEDTMGL EYASGMDATR SLGDPPHAMA
     RAGSFSTSGP GSSQEGSHFL SSRHSQSSGM YQPVPKRPSC SCLKLQASAL CRIHLVDRSH
     ADMRGDTVLA TASTILDSCN ALILCPSCAT DYKFLLLAIM TVRILLCWLR GLSATRTQND
     NANMKLTLGE YEISGEEEAI IKNMLVSRAL EKVKIAVRRL RERVNSITIQ EVGNCSESTQ
     RWDLTYIRMC LDHMEKQVGC