BH153_ARATH
ID BH153_ARATH Reviewed; 149 AA.
AC Q7XJU2; B9DHI3; Q8LAF0; Q8VY82; Q9SYL2;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Transcription factor bHLH153;
DE AltName: Full=BHLH transcription factor alpha;
DE Short=bHLH alpha {ECO:0000312|EMBL:CAE09167.1};
DE AltName: Full=Basic helix-loop-helix protein 153;
DE Short=AtbHLH153 {ECO:0000303|PubMed:14600211};
DE Short=bHLH 153;
DE AltName: Full=bHLH transcription factor bHLH153;
GN Name=BHLH153 {ECO:0000303|PubMed:14600211};
GN OrderedLocusNames=At1g05710 {ECO:0000312|Araport:AT1G05710};
GN ORFNames=F3F20.16 {ECO:0000312|EMBL:AAD30624.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-149 (ISOFORM 1).
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf {ECO:0000312|EMBL:BAH20200.1};
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
CC -!- INTERACTION:
CC Q7XJU2; Q93Y00: BHLH7; NbExp=4; IntAct=EBI-4427748, EBI-4442198;
CC Q7XJU2; Q17TI5: BRX; NbExp=5; IntAct=EBI-4427748, EBI-4426649;
CC Q7XJU2; Q9S7W5: TCP13; NbExp=3; IntAct=EBI-4427748, EBI-4424877;
CC Q7XJU2; Q93Z00: TCP14; NbExp=3; IntAct=EBI-4427748, EBI-4424563;
CC Q7XJU2; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-4427748, EBI-4426144;
CC Q7XJU2; Q9LQF0: TCP23; NbExp=3; IntAct=EBI-4427748, EBI-15192297;
CC Q7XJU2; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-4427748, EBI-15192325;
CC Q7XJU2; Q9FMX2: TCP7; NbExp=3; IntAct=EBI-4427748, EBI-15192677;
CC Q7XJU2; O64647: TCP9; NbExp=3; IntAct=EBI-4427748, EBI-9838721;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7XJU2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7XJU2-2; Sequence=VSP_058844;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bHLH protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD30624.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM65410.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ576040; CAE09167.1; -; mRNA.
DR EMBL; AC007153; AAD30624.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27879.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27880.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27882.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27883.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27881.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60670.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60671.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60672.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60673.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60674.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60675.1; -; Genomic_DNA.
DR EMBL; AY072363; AAL62355.1; -; mRNA.
DR EMBL; BT006558; AAP21366.1; -; mRNA.
DR EMBL; AK230257; BAF02059.1; -; mRNA.
DR EMBL; AY087858; AAM65410.1; ALT_INIT; mRNA.
DR EMBL; AK317536; BAH20200.1; -; mRNA.
DR PIR; D86191; D86191.
DR RefSeq; NP_001184916.1; NM_001197987.1. [Q7XJU2-1]
DR RefSeq; NP_001322940.1; NM_001331570.1. [Q7XJU2-2]
DR RefSeq; NP_001322941.1; NM_001331568.1. [Q7XJU2-1]
DR RefSeq; NP_001322942.1; NM_001331567.1. [Q7XJU2-2]
DR RefSeq; NP_001322943.1; NM_001331566.1. [Q7XJU2-1]
DR RefSeq; NP_001322944.1; NM_001331565.1. [Q7XJU2-1]
DR RefSeq; NP_001322945.1; NM_001331564.1. [Q7XJU2-2]
DR RefSeq; NP_563746.1; NM_100451.4. [Q7XJU2-1]
DR RefSeq; NP_849597.1; NM_179266.3. [Q7XJU2-2]
DR RefSeq; NP_973764.1; NM_202035.4. [Q7XJU2-1]
DR RefSeq; NP_973765.1; NM_202036.3. [Q7XJU2-1]
DR AlphaFoldDB; Q7XJU2; -.
DR SMR; Q7XJU2; -.
DR IntAct; Q7XJU2; 38.
DR iPTMnet; Q7XJU2; -.
DR PRIDE; Q7XJU2; -.
DR ProteomicsDB; 240685; -. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.1; AT1G05710.1; AT1G05710. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.10; AT1G05710.10; AT1G05710. [Q7XJU2-2]
DR EnsemblPlants; AT1G05710.11; AT1G05710.11; AT1G05710. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.12; AT1G05710.12; AT1G05710. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.13; AT1G05710.13; AT1G05710. [Q7XJU2-2]
DR EnsemblPlants; AT1G05710.14; AT1G05710.14; AT1G05710. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.2; AT1G05710.2; AT1G05710. [Q7XJU2-2]
DR EnsemblPlants; AT1G05710.3; AT1G05710.3; AT1G05710. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.4; AT1G05710.4; AT1G05710. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.5; AT1G05710.5; AT1G05710. [Q7XJU2-1]
DR EnsemblPlants; AT1G05710.7; AT1G05710.7; AT1G05710. [Q7XJU2-2]
DR GeneID; 837078; -.
DR Gramene; AT1G05710.1; AT1G05710.1; AT1G05710. [Q7XJU2-1]
DR Gramene; AT1G05710.10; AT1G05710.10; AT1G05710. [Q7XJU2-2]
DR Gramene; AT1G05710.11; AT1G05710.11; AT1G05710. [Q7XJU2-1]
DR Gramene; AT1G05710.12; AT1G05710.12; AT1G05710. [Q7XJU2-1]
DR Gramene; AT1G05710.13; AT1G05710.13; AT1G05710. [Q7XJU2-2]
DR Gramene; AT1G05710.14; AT1G05710.14; AT1G05710. [Q7XJU2-1]
DR Gramene; AT1G05710.2; AT1G05710.2; AT1G05710. [Q7XJU2-2]
DR Gramene; AT1G05710.3; AT1G05710.3; AT1G05710. [Q7XJU2-1]
DR Gramene; AT1G05710.4; AT1G05710.4; AT1G05710. [Q7XJU2-1]
DR Gramene; AT1G05710.5; AT1G05710.5; AT1G05710. [Q7XJU2-1]
DR Gramene; AT1G05710.7; AT1G05710.7; AT1G05710. [Q7XJU2-2]
DR KEGG; ath:AT1G05710; -.
DR Araport; AT1G05710; -.
DR TAIR; locus:2031978; AT1G05710.
DR PhylomeDB; Q7XJU2; -.
DR PRO; PR:Q7XJU2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q7XJU2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11393; bHLH_AtbHLH_like; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045239; bHLH95_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..149
FT /note="Transcription factor bHLH153"
FT /id="PRO_0000439391"
FT DOMAIN 27..76
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT VAR_SEQ 81
FT /note="K -> KVCSSIPSMIHSSLSEFPCSFVQ (in isoform 2)"
FT /id="VSP_058844"
FT CONFLICT 5
FT /note="R -> G (in Ref. 6; AAM65410)"
FT /evidence="ECO:0000305"
FT CONFLICT 35
FT /note="S -> N (in Ref. 6; AAM65410)"
FT /evidence="ECO:0000305"
FT CONFLICT 91
FT /note="V -> I (in Ref. 6; AAM65410)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 149 AA; 16611 MW; C1BA62D129E31831 CRC64;
MEFSRDAGMM MENKRNVCSL GESSIKRHKS DLSFSSKERK DKVGERISAL QQIVSPYGKT
DTASVLLDAM HYIEFLHEQV KVLSAPYLQT VPDATQEELE QYSLRNRGLC LVPMENTVGV
AQSNGADIWA PVKTPLSPAF SVTSQSPFR
