ID   SIS2_CANTR              Reviewed;         531 AA.
AC   Q12600;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Protein SIS2;
DE   AltName: Full=Halotolerance protein HAL3;
GN   Name=SIS2; Synonyms=HAL3;
OS   Candida tropicalis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCYC 2512;
RX   PubMed=8923737;
RX   DOI=10.1002/(sici)1097-0061(199610)12:13<1321::aid-yea27>3.0.co;2-6;
RA   Rodriguez P.L., Ali R., Serrano R.;
RT   "CtCdc55p and CtHa13p: two putative regulatory proteins from Candida
RT   tropicalis with long acidic domains.";
RL   Yeast 12:1321-1329(1996).
CC   -!- FUNCTION: May stimulate expression of certain genes that are
CC       periodically expressed during late G1. Also modulates the expression of
CC       the ENA1 ATPase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HFCD (homooligomeric flavin containing Cys
CC       decarboxylase) superfamily. {ECO:0000305}.
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DR   EMBL; X88900; CAA61362.1; -; Genomic_DNA.
DR   PIR; S57752; S57752.
DR   AlphaFoldDB; Q12600; -.
DR   SMR; Q12600; -.
DR   VEuPathDB; FungiDB:CTMYA2_009710; -.
DR   VEuPathDB; FungiDB:CTRG_05660; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1950; -; 1.
DR   InterPro; IPR036551; Flavin_trans-like.
DR   InterPro; IPR003382; Flavoprotein.
DR   Pfam; PF02441; Flavoprotein; 1.
DR   SUPFAM; SSF52507; SSF52507; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus.
FT   CHAIN           1..531
FT                   /note="Protein SIS2"
FT                   /id="PRO_0000182036"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..516
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..531
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   531 AA;  58172 MW;  D5FF196B8B957B14 CRC64;
     MPSDKDIKSP AQPKKEEEIP KSILTRISSP PPILNQPDAN IIHHPQPQVP QSSLNIPGIK
     LSPQISTSLE NREIVMAGGA YLKERMESPD SLNHKPTLLQ PDKSESIPSI DYTLNPPKES
     QHHKSPSVHA HFYVEETLRP VRNRSRSGSN SNNNLTPITS PQHSEPSSIL NKDAIKSQES
     LRATTNSISS AAASNQSTPR SIISGGGGGG GGANTATSSN STTSNTALAA QGTTTTTTTT
     NSNSNTTTTK GEQNSNIDPR LPQDDGKFHV LIGVCGALSV GKVKLIVNKL LEIYTSDKIS
     IQVILTKSSE NFLLPETLNV LENVKKVRVW TDIDEWTTWK TRLDPVLHIE LRRWADILLV
     CPLTANTLAK ISLGICDNLL TNVIRAWNSS YPILLAPAMD SHSYSSSTTK RQLRLIADDM
     PWIEVLKPLE KVFGSYGDIG MGGMTDWNEI VNRIVMKLGG YPEDEDEDEA DDSKDNIDES
     AIIDDDDDDD DDDDDDDDDD DDDDDDDDDD EEDPPQQQST TDNSKDETTN L