ID   SIS_LYMST               Reviewed;         100 AA.
AC   P42579;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Sodium-influx-stimulating peptide;
DE   Flags: Precursor;
GN   Name=SIS;
OS   Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Lymnaeidae; Lymnaea.
OX   NCBI_TaxID=6523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neuron;
RX   PubMed=8344306; DOI=10.1111/j.1432-1033.1993.tb18046.x;
RA   Smit A.B., Thijsen S.F.T., Geraerts W.P.M.;
RT   "cDNA cloning of the sodium-influx-stimulating peptide in the mollusc,
RT   Lymnaea stagnalis.";
RL   Eur. J. Biochem. 215:397-400(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-99.
RC   TISSUE=CNS;
RX   PubMed=8234026; DOI=10.1016/0196-9781(93)90114-v;
RA   de With N.D., van der Schors R.C., Boer H.H., Ebberink R.H.M.;
RT   "The sodium influx stimulating peptide of the pulmonate freshwater snail
RT   Lymnaea stagnalis.";
RL   Peptides 14:783-789(1993).
CC   -!- FUNCTION: Stimulates integumental Na(+) uptake. Controls the activity
CC       of sodium pumps in the integument, pericardium, ureter and nephridial
CC       gland.
CC   -!- TISSUE SPECIFICITY: Expressed by the yellow cells, peptidergic
CC       (neuroendocrine) neurons of the central nervous system.
CC   -!- PTM: Three disulfide bonds are present. {ECO:0000305}.
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DR   EMBL; X73157; CAA51680.1; -; mRNA.
DR   PIR; S34772; S34772.
DR   AlphaFoldDB; P42579; -.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:8234026"
FT   CHAIN           24..100
FT                   /note="Sodium-influx-stimulating peptide"
FT                   /id="PRO_0000022348"
SQ   SEQUENCE   100 AA;  11463 MW;  AF4885A207E8E688 CRC64;
     MLSSVALRYL LVLSLAFLAV VTSSRTQSRF ASYELMGTEG TECVTTKTIS QICYQCATRH
     EDSFVQVYQE CCKKEMGLRE YCEEIYTELP IRSGLWQPNK