ID   SIT_SEGFL               Reviewed;          35 AA.
AC   P61504;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=U1-segestritoxin-Sf1a {ECO:0000305};
DE            Short=U1-SGTX-Sf1a {ECO:0000305};
DE   AltName: Full=Insectotoxin SIT {ECO:0000303|PubMed:3675645};
OS   Segestria florentina (Tube-web spider) (Segestria gracilis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Haplogynae; Dysderoidea; Segestriidae; Segestria.
OX   NCBI_TaxID=31925;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=3675645;
RA   Sagdiev N.Z., Valieva L.A., Korneev A.S., Sadykov A.A., Salikhov S.I.;
RT   "Toxic components of the venom of the cellar spider Segestria florentina.";
RL   Bioorg. Khim. 13:1013-1018(1987).
CC   -!- FUNCTION: Insecticidal toxin. {ECO:0000269|PubMed:3675645}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3675645}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:3675645}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 16 (SFI) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P61504; -.
DR   ArachnoServer; AS000125; U1-segestritoxin-Sf1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012633; Toxin_28.
DR   Pfam; PF08115; Toxin_28; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   PEPTIDE         1..35
FT                   /note="U1-segestritoxin-Sf1a"
FT                   /evidence="ECO:0000269|PubMed:3675645"
FT                   /id="PRO_0000044967"
FT   REGION          31..33
FT                   /note="Keys region for toxin activity"
FT                   /evidence="ECO:0000250|UniProtKB:P61095"
FT   DISULFID        10..22
FT                   /evidence="ECO:0000250|UniProtKB:P61095"
FT   DISULFID        17..28
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   35 AA;  3972 MW;  863F2D2E5E997989 CRC64;
     RQDMVDESVC YITDNNCNGG KCLRSKACHA DPWEL